| # | Player | Team | W | L | ERA | G | GS | SV | IP | H | HR | BB | SO | WHIP | K% | BB% |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | George Sherrill | LAD | 1 | 1 | 1.70 | 72 | 0 | 21 | 69.0 | 53 | 4 | 24 | 61 | 1.12 | 21.6 | 8.5 |
| 2 | Jeremy Affeldt | SF | 2 | 2 | 1.73 | 74 | 0 | 0 | 62.3 | 42 | 3 | 31 | 55 | 1.17 | 22.2 | 12.5 |
| 3 | Claudio Vargas | MIL | 1 | 0 | 1.74 | 36 | 0 | 0 | 41.3 | 25 | 3 | 15 | 30 | 0.97 | 18.9 | 9.4 |
| 4 | Mariano Rivera | NYY | 3 | 3 | 1.76 | 66 | 0 | 44 | 66.3 | 48 | 7 | 12 | 72 | 0.90 | 28.0 | 4.7 |
| 5 | Trevor Hoffman | MIL | 3 | 2 | 1.83 | 55 | 0 | 37 | 54.0 | 35 | 2 | 14 | 48 | 0.91 | 22.9 | 6.7 |
| 6 | Andrew Bailey | OAK | 6 | 3 | 1.84 | 68 | 0 | 26 | 83.3 | 49 | 5 | 24 | 91 | 0.88 | 28.2 | 7.4 |
| 7 | Darren O'Day | TEX | 2 | 1 | 1.84 | 68 | 0 | 2 | 58.7 | 41 | 3 | 18 | 56 | 1.01 | 24.0 | 7.7 |
| 8 | Jonathan Papelbon | BOS | 1 | 1 | 1.85 | 66 | 0 | 38 | 68.0 | 54 | 5 | 24 | 76 | 1.15 | 26.7 | 8.4 |
| 9 | Ryan Franklin | STL | 4 | 3 | 1.92 | 62 | 0 | 38 | 61.0 | 49 | 2 | 24 | 44 | 1.20 | 17.6 | 9.6 |
| 10 | Kiko Calero | FLO | 2 | 2 | 1.95 | 67 | 0 | 0 | 60.0 | 36 | 1 | 30 | 69 | 1.10 | 28.9 | 12.6 |
| 11 | Blake Hawksworth | STL | 4 | 0 | 2.02 | 30 | 0 | 0 | 40.0 | 29 | 2 | 15 | 20 | 1.10 | 12.5 | 9.4 |
| 12 | Ronald Belisario | LAD | 4 | 3 | 2.04 | 69 | 0 | 0 | 70.7 | 52 | 4 | 29 | 64 | 1.15 | 21.4 | 9.7 |
| 13 | Trever Miller | STL | 4 | 1 | 2.06 | 70 | 0 | 0 | 43.7 | 31 | 5 | 11 | 46 | 0.96 | 26.6 | 6.4 |
| 14 | Joe Nathan | MIN | 2 | 2 | 2.10 | 70 | 0 | 47 | 68.7 | 42 | 7 | 22 | 89 | 0.93 | 32.8 | 8.1 |
| 15 | LaTroy Hawkins | HOU | 1 | 4 | 2.13 | 65 | 0 | 11 | 63.3 | 60 | 7 | 16 | 45 | 1.20 | 17.4 | 6.2 |
| 16 | Zack Greinke | KC | 16 | 8 | 2.16 | 33 | 33 | 0 | 229.3 | 195 | 11 | 51 | 242 | 1.07 | 26.4 | 5.6 |
| 17 | Francisco Cordero | CIN | 2 | 6 | 2.16 | 68 | 0 | 39 | 66.7 | 58 | 2 | 30 | 58 | 1.32 | 21.0 | 10.9 |
| 18 | Joakim Soria | KC | 3 | 2 | 2.21 | 47 | 0 | 30 | 53.0 | 44 | 5 | 16 | 69 | 1.13 | 31.1 | 7.2 |
| 19 | Chris Carpenter | STL | 17 | 4 | 2.24 | 28 | 28 | 0 | 192.7 | 156 | 7 | 38 | 144 | 1.01 | 19.2 | 5.1 |
| 20 | Jose Valverde | HOU | 4 | 2 | 2.33 | 52 | 0 | 25 | 54.0 | 40 | 5 | 21 | 56 | 1.13 | 25.6 | 9.6 |
| 21 | Jose Mijares | MIN | 2 | 2 | 2.34 | 71 | 0 | 0 | 61.7 | 50 | 7 | 23 | 55 | 1.18 | 21.7 | 9.1 |
| 22 | Matt Guerrier | MIN | 5 | 1 | 2.36 | 79 | 0 | 1 | 76.3 | 58 | 10 | 16 | 47 | 0.97 | 15.5 | 5.3 |
| 23 | Nick Masset | CIN | 5 | 1 | 2.37 | 74 | 0 | 0 | 76.0 | 54 | 6 | 24 | 70 | 1.03 | 24.0 | 8.2 |
| 24 | Mike Gonzalez | ATL | 5 | 4 | 2.42 | 80 | 0 | 10 | 74.3 | 56 | 7 | 33 | 90 | 1.20 | 28.6 | 10.5 |
| 25 | Takashi Saito | BOS | 3 | 3 | 2.43 | 56 | 0 | 2 | 55.7 | 50 | 6 | 25 | 52 | 1.35 | 21.7 | 10.4 |
| 26 | Tim Lincecum | SF | 15 | 7 | 2.48 | 32 | 32 | 0 | 225.3 | 168 | 10 | 68 | 261 | 1.05 | 28.8 | 7.5 |
| 27 | Felix Hernandez | SEA | 19 | 5 | 2.49 | 34 | 34 | 0 | 238.7 | 200 | 15 | 71 | 217 | 1.14 | 22.2 | 7.3 |
| 28 | Jason Frasor | TOR | 7 | 3 | 2.50 | 61 | 0 | 11 | 57.7 | 43 | 4 | 16 | 56 | 1.02 | 24.7 | 7.0 |
| 29 | David Aardsma | SEA | 3 | 6 | 2.52 | 73 | 0 | 38 | 71.3 | 49 | 4 | 34 | 80 | 1.16 | 27.0 | 11.5 |
| 30 | Arthur Rhodes | CIN | 1 | 1 | 2.53 | 66 | 0 | 0 | 53.3 | 37 | 3 | 20 | 48 | 1.07 | 22.3 | 9.3 |
| 31 | Brian Sanches | FLO | 4 | 2 | 2.56 | 47 | 0 | 0 | 56.3 | 50 | 5 | 26 | 51 | 1.35 | 20.6 | 10.5 |
| 32 | Jair Jurrjens | ATL | 14 | 10 | 2.60 | 34 | 34 | 0 | 215.0 | 186 | 15 | 75 | 152 | 1.21 | 17.2 | 8.5 |
| 33 | Jonathan Broxton | LAD | 7 | 2 | 2.61 | 73 | 0 | 36 | 76.0 | 44 | 4 | 29 | 114 | 0.96 | 38.0 | 9.7 |
| 34 | Adam Wainwright | STL | 19 | 8 | 2.63 | 34 | 34 | 0 | 233.0 | 216 | 17 | 66 | 212 | 1.21 | 21.9 | 6.8 |
| 35 | Michael Wuertz | OAK | 6 | 1 | 2.63 | 74 | 0 | 4 | 78.7 | 52 | 6 | 23 | 102 | 0.95 | 33.6 | 7.6 |
| 36 | Tyler Clippard | WSH | 4 | 2 | 2.69 | 41 | 0 | 0 | 60.3 | 36 | 9 | 32 | 67 | 1.13 | 27.2 | 13.0 |
| 37 | Darren Oliver | LAA | 5 | 1 | 2.71 | 63 | 1 | 0 | 73.0 | 61 | 5 | 22 | 65 | 1.14 | 22.2 | 7.5 |
| 38 | Heath Bell | SD | 6 | 4 | 2.71 | 68 | 0 | 42 | 69.7 | 54 | 3 | 24 | 79 | 1.12 | 28.4 | 8.6 |
| 39 | Ramon Troncoso | LAD | 5 | 4 | 2.72 | 73 | 0 | 6 | 82.7 | 83 | 3 | 34 | 55 | 1.42 | 15.4 | 9.5 |
| 40 | Rafael Betancourt | COL | 4 | 3 | 2.73 | 61 | 0 | 2 | 56.0 | 42 | 4 | 20 | 61 | 1.11 | 26.9 | 8.8 |
| 41 | Brian Wilson | SF | 5 | 6 | 2.74 | 68 | 0 | 38 | 72.3 | 60 | 3 | 27 | 83 | 1.20 | 27.4 | 8.9 |
| 42 | Matt Thornton | CWS | 6 | 3 | 2.74 | 70 | 0 | 4 | 72.3 | 58 | 5 | 20 | 87 | 1.08 | 29.9 | 6.9 |
| 43 | Roy Halladay | TOR | 17 | 10 | 2.79 | 32 | 32 | 0 | 239.0 | 234 | 22 | 35 | 208 | 1.13 | 21.6 | 3.6 |
| 44 | Clayton Kershaw | LAD | 8 | 8 | 2.79 | 31 | 30 | 0 | 171.0 | 119 | 7 | 91 | 185 | 1.23 | 26.4 | 13.0 |
| 45 | Sean White | SEA | 3 | 2 | 2.80 | 52 | 0 | 1 | 64.3 | 50 | 3 | 20 | 28 | 1.09 | 10.7 | 7.7 |
| 46 | Joe Thatcher | SD | 1 | 0 | 2.80 | 52 | 0 | 0 | 45.0 | 37 | 2 | 18 | 55 | 1.22 | 29.3 | 9.6 |
| 47 | C. J. Wilson | TEX | 5 | 6 | 2.81 | 74 | 0 | 14 | 73.7 | 66 | 3 | 32 | 84 | 1.33 | 26.0 | 9.9 |
| 48 | Erik Bedard | SEA | 5 | 3 | 2.82 | 15 | 15 | 0 | 83.0 | 65 | 8 | 34 | 90 | 1.19 | 25.9 | 9.8 |
| 49 | J. P. Howell | TB | 7 | 5 | 2.83 | 69 | 0 | 17 | 66.7 | 47 | 7 | 33 | 79 | 1.20 | 28.4 | 11.9 |
| 50 | Peter Moylan | ATL | 6 | 2 | 2.84 | 87 | 0 | 0 | 73.0 | 65 | 0 | 35 | 61 | 1.37 | 19.7 | 11.3 |
| 51 | Ramon Ramirez | BOS | 7 | 4 | 2.84 | 70 | 0 | 0 | 69.7 | 61 | 7 | 32 | 52 | 1.33 | 17.3 | 10.6 |
| 52 | Brandon Lyon | DET | 6 | 5 | 2.86 | 65 | 0 | 3 | 78.7 | 56 | 7 | 31 | 57 | 1.11 | 18.2 | 9.9 |
| 53 | Javier Vazquez | ATL | 15 | 10 | 2.87 | 32 | 32 | 0 | 219.3 | 181 | 20 | 44 | 238 | 1.03 | 27.2 | 5.0 |
| 54 | Tommy Hanson | ATL | 11 | 4 | 2.89 | 21 | 21 | 0 | 127.7 | 105 | 10 | 46 | 116 | 1.18 | 22.2 | 8.8 |
| 55 | Matt Cain | SF | 14 | 8 | 2.89 | 33 | 33 | 0 | 217.7 | 184 | 22 | 73 | 171 | 1.18 | 19.3 | 8.2 |
| 56 | Todd Coffey | MIL | 4 | 4 | 2.90 | 78 | 0 | 2 | 83.7 | 76 | 8 | 21 | 65 | 1.16 | 19.3 | 6.2 |
| 57 | Tony Sipp | CLE | 2 | 0 | 2.92 | 46 | 0 | 0 | 40.0 | 27 | 5 | 25 | 48 | 1.30 | 28.6 | 14.9 |
| 58 | J. A. Happ | PHI | 12 | 4 | 2.93 | 35 | 23 | 0 | 166.0 | 149 | 20 | 56 | 119 | 1.23 | 17.4 | 8.2 |
| 59 | Angel Guzman | CHC | 3 | 3 | 2.95 | 55 | 0 | 1 | 61.0 | 41 | 8 | 23 | 47 | 1.05 | 19.2 | 9.4 |
| 60 | Rafael Soriano | ATL | 1 | 6 | 2.97 | 77 | 0 | 27 | 75.7 | 53 | 6 | 27 | 102 | 1.06 | 33.2 | 8.8 |
| 61 | Clay Condrey | PHI | 6 | 2 | 3.00 | 45 | 0 | 1 | 42.0 | 37 | 4 | 14 | 25 | 1.21 | 14.4 | 8.0 |
| 62 | Brandon Medders | SF | 5 | 1 | 3.01 | 61 | 0 | 1 | 68.7 | 63 | 6 | 32 | 58 | 1.38 | 19.3 | 10.7 |
| 63 | Wandy Rodriguez | HOU | 14 | 12 | 3.02 | 33 | 33 | 0 | 205.7 | 192 | 21 | 63 | 193 | 1.24 | 22.7 | 7.4 |
| 64 | Pedro Feliciano | NYM | 6 | 4 | 3.03 | 88 | 0 | 0 | 59.3 | 51 | 7 | 18 | 59 | 1.16 | 24.4 | 7.4 |
| 65 | Phil Hughes | NYY | 8 | 3 | 3.03 | 51 | 7 | 3 | 86.0 | 68 | 8 | 28 | 96 | 1.12 | 27.4 | 8.0 |
| 66 | Eric O'Flaherty | ATL | 2 | 1 | 3.04 | 78 | 0 | 0 | 56.3 | 52 | 2 | 18 | 39 | 1.24 | 16.5 | 7.6 |
| 67 | Randy Wells | CHC | 12 | 10 | 3.05 | 27 | 27 | 0 | 165.3 | 165 | 14 | 46 | 104 | 1.28 | 15.0 | 6.6 |
| 68 | Danny Herrera | CIN | 4 | 4 | 3.06 | 70 | 0 | 0 | 61.7 | 63 | 5 | 24 | 44 | 1.41 | 16.8 | 9.2 |
| 69 | Huston Street | COL | 4 | 1 | 3.06 | 64 | 0 | 35 | 61.7 | 43 | 7 | 13 | 70 | 0.91 | 29.2 | 5.4 |
| 70 | Brad Ziegler | OAK | 2 | 4 | 3.07 | 69 | 0 | 7 | 73.3 | 82 | 2 | 28 | 54 | 1.50 | 17.3 | 8.9 |
| 71 | Dan Meyer | FLO | 3 | 2 | 3.09 | 71 | 0 | 2 | 58.3 | 47 | 7 | 21 | 56 | 1.17 | 23.1 | 8.7 |
| 72 | Scott Downs | TOR | 1 | 3 | 3.09 | 48 | 0 | 9 | 46.7 | 46 | 4 | 13 | 43 | 1.26 | 21.5 | 6.5 |
| 73 | Ted Lilly | CHC | 12 | 9 | 3.10 | 27 | 27 | 0 | 177.0 | 151 | 22 | 36 | 151 | 1.06 | 21.4 | 5.1 |
| 74 | Sean Burnett | WSH | 2 | 3 | 3.12 | 71 | 0 | 1 | 57.7 | 36 | 6 | 28 | 43 | 1.11 | 18.1 | 11.8 |
| 75 | Johan Santana | NYM | 13 | 9 | 3.13 | 25 | 25 | 0 | 166.7 | 156 | 20 | 46 | 146 | 1.21 | 20.8 | 6.6 |
| 76 | Dan Haren | ARI | 14 | 10 | 3.14 | 33 | 33 | 0 | 229.3 | 192 | 27 | 38 | 223 | 1.00 | 24.5 | 4.2 |
| 77 | Steven Jackson | PIT | 2 | 3 | 3.14 | 40 | 0 | 0 | 43.0 | 38 | 2 | 22 | 21 | 1.40 | 11.3 | 11.8 |
| 78 | Doug Mathis | TEX | 0 | 1 | 3.16 | 24 | 2 | 1 | 42.7 | 39 | 4 | 10 | 25 | 1.15 | 14.5 | 5.8 |
| 79 | Justin Miller | SF | 3 | 3 | 3.18 | 44 | 0 | 0 | 56.7 | 47 | 7 | 27 | 36 | 1.31 | 15.3 | 11.4 |
| 80 | Cliff Lee | PHI | 14 | 13 | 3.22 | 34 | 34 | 0 | 231.7 | 245 | 17 | 43 | 181 | 1.24 | 18.7 | 4.4 |
| 81 | Tim Byrdak | HOU | 1 | 2 | 3.23 | 76 | 0 | 0 | 61.3 | 39 | 10 | 36 | 58 | 1.22 | 22.2 | 13.8 |
| 82 | Renyel Pinto | FLO | 4 | 1 | 3.23 | 73 | 0 | 0 | 61.3 | 53 | 4 | 45 | 58 | 1.60 | 21.1 | 16.4 |
| 83 | Josh Johnson | FLO | 15 | 5 | 3.23 | 33 | 33 | 0 | 209.0 | 184 | 14 | 58 | 191 | 1.16 | 22.3 | 6.8 |
| 84 | Randy Wolf | LAD | 11 | 7 | 3.23 | 34 | 34 | 0 | 214.3 | 178 | 24 | 58 | 160 | 1.10 | 18.6 | 6.7 |
| 85 | Luke Gregerson | SD | 2 | 4 | 3.24 | 72 | 0 | 1 | 75.0 | 62 | 3 | 31 | 93 | 1.24 | 29.2 | 9.7 |
| 86 | Lance Cormier | TB | 3 | 3 | 3.26 | 53 | 0 | 2 | 77.3 | 75 | 6 | 25 | 36 | 1.29 | 10.9 | 7.6 |
| 87 | Ryan Madson | PHI | 5 | 5 | 3.26 | 79 | 0 | 10 | 77.3 | 73 | 7 | 22 | 78 | 1.23 | 24.4 | 6.9 |
| 88 | Mark Lowe | SEA | 2 | 7 | 3.26 | 75 | 0 | 3 | 80.0 | 71 | 7 | 29 | 69 | 1.25 | 20.4 | 8.6 |
| 89 | Dan Wheeler | TB | 4 | 5 | 3.28 | 69 | 0 | 2 | 57.7 | 41 | 11 | 9 | 45 | 0.87 | 20.5 | 4.1 |
| 90 | Dennys Reyes | STL | 0 | 2 | 3.29 | 75 | 0 | 1 | 41.0 | 35 | 2 | 21 | 33 | 1.37 | 18.3 | 11.7 |
| 91 | David Robertson | NYY | 2 | 1 | 3.30 | 45 | 0 | 1 | 43.7 | 36 | 4 | 23 | 63 | 1.35 | 33.0 | 12.0 |
| 92 | Octavio Dotel | CWS | 3 | 3 | 3.32 | 62 | 0 | 0 | 62.3 | 54 | 7 | 36 | 75 | 1.44 | 28.0 | 13.4 |
| 93 | Alberto Arias | HOU | 2 | 1 | 3.35 | 42 | 0 | 0 | 45.7 | 49 | 1 | 19 | 39 | 1.49 | 18.7 | 9.1 |
| 94 | Clay Zavada | ARI | 3 | 3 | 3.35 | 49 | 0 | 0 | 51.0 | 45 | 5 | 24 | 52 | 1.35 | 23.5 | 10.9 |
| 95 | Craig Breslow | OAK | 8 | 7 | 3.36 | 77 | 0 | 0 | 69.7 | 48 | 8 | 29 | 55 | 1.11 | 19.6 | 10.3 |
| 96 | John Grabow | CHC | 3 | 0 | 3.36 | 75 | 0 | 0 | 72.3 | 62 | 5 | 40 | 57 | 1.41 | 18.2 | 12.7 |
| 97 | CC Sabathia | NYY | 19 | 8 | 3.37 | 34 | 34 | 0 | 230.0 | 197 | 18 | 67 | 197 | 1.15 | 21.0 | 7.1 |
| 98 | Kyle McClellan | STL | 4 | 4 | 3.37 | 66 | 0 | 3 | 66.7 | 56 | 4 | 34 | 51 | 1.35 | 17.7 | 11.8 |
| 99 | Bob Howry | SF | 2 | 6 | 3.39 | 63 | 0 | 0 | 63.7 | 50 | 5 | 23 | 46 | 1.15 | 17.2 | 8.6 |
| 100 | Hideki Okajima | BOS | 6 | 0 | 3.39 | 68 | 0 | 0 | 61.0 | 56 | 8 | 21 | 53 | 1.26 | 20.5 | 8.1 |
| 101 | Jeff Fulchino | HOU | 6 | 4 | 3.40 | 61 | 0 | 0 | 82.0 | 70 | 7 | 27 | 71 | 1.18 | 21.1 | 8.0 |
| 102 | Carlos Marmol | CHC | 2 | 4 | 3.41 | 79 | 0 | 15 | 74.0 | 43 | 2 | 65 | 93 | 1.46 | 27.8 | 19.4 |
| 103 | Jon Lester | BOS | 15 | 8 | 3.41 | 32 | 32 | 0 | 203.3 | 186 | 20 | 64 | 225 | 1.23 | 26.7 | 7.6 |
| 104 | Brad Bergesen | BAL | 7 | 5 | 3.43 | 19 | 19 | 0 | 123.3 | 126 | 11 | 32 | 65 | 1.28 | 12.5 | 6.2 |
| 105 | Guillermo Mota | LAD | 3 | 4 | 3.44 | 61 | 0 | 0 | 65.3 | 53 | 6 | 24 | 39 | 1.18 | 14.3 | 8.8 |
| 106 | Evan Meek | PIT | 1 | 1 | 3.45 | 41 | 0 | 0 | 47.0 | 34 | 2 | 29 | 42 | 1.34 | 21.5 | 14.9 |
| 107 | Justin Verlander | DET | 19 | 9 | 3.45 | 35 | 35 | 0 | 240.0 | 219 | 20 | 63 | 269 | 1.18 | 27.4 | 6.4 |
| 108 | Jake Peavy | CWS | 9 | 6 | 3.45 | 16 | 16 | 0 | 101.7 | 80 | 8 | 34 | 110 | 1.12 | 26.8 | 8.3 |
| 109 | Ubaldo Jimenez | COL | 15 | 12 | 3.47 | 33 | 33 | 0 | 218.0 | 183 | 13 | 85 | 198 | 1.23 | 21.7 | 9.3 |
| 110 | Josh Outman | OAK | 4 | 1 | 3.48 | 14 | 12 | 0 | 67.3 | 53 | 9 | 25 | 53 | 1.16 | 19.2 | 9.1 |
| 111 | Joel Pineiro | STL | 15 | 12 | 3.49 | 32 | 32 | 0 | 214.0 | 218 | 11 | 27 | 105 | 1.14 | 12.1 | 3.1 |
| 112 | Shawn Camp | TOR | 2 | 6 | 3.50 | 59 | 0 | 1 | 79.7 | 73 | 7 | 29 | 58 | 1.28 | 17.4 | 8.7 |
| 113 | Alfredo Aceves | NYY | 10 | 1 | 3.54 | 43 | 1 | 1 | 84.0 | 69 | 10 | 16 | 69 | 1.01 | 20.5 | 4.7 |
| 114 | Rob Tejeda | KC | 4 | 2 | 3.54 | 35 | 6 | 0 | 73.7 | 43 | 4 | 50 | 87 | 1.26 | 27.8 | 16.0 |
| 115 | Jason Bulger | LAA | 6 | 1 | 3.56 | 64 | 0 | 1 | 65.7 | 46 | 7 | 30 | 68 | 1.16 | 26.0 | 11.5 |
| 116 | Tim Stauffer | SD | 4 | 7 | 3.58 | 14 | 14 | 0 | 73.0 | 71 | 8 | 34 | 53 | 1.44 | 16.8 | 10.8 |
| 117 | Joe Beimel | COL | 1 | 6 | 3.58 | 71 | 0 | 1 | 55.3 | 57 | 5 | 19 | 35 | 1.37 | 14.6 | 7.9 |
| 118 | Mitch Stetter | MIL | 4 | 1 | 3.60 | 71 | 0 | 1 | 45.0 | 37 | 4 | 27 | 44 | 1.42 | 21.7 | 13.3 |
| 119 | Jon Rauch | MIN | 7 | 3 | 3.60 | 75 | 0 | 2 | 70.0 | 70 | 6 | 23 | 49 | 1.33 | 16.4 | 7.7 |
| 120 | Tim Hudson | ATL | 2 | 1 | 3.61 | 7 | 7 | 0 | 42.3 | 49 | 4 | 13 | 30 | 1.46 | 16.7 | 7.2 |
| 121 | Edwin Jackson | DET | 13 | 9 | 3.62 | 33 | 33 | 0 | 214.0 | 200 | 27 | 70 | 161 | 1.26 | 18.1 | 7.9 |
| 122 | Pedro Martinez | PHI | 5 | 1 | 3.63 | 9 | 9 | 0 | 44.7 | 48 | 7 | 8 | 37 | 1.25 | 19.4 | 4.2 |
| 123 | Chad Qualls | ARI | 2 | 2 | 3.63 | 51 | 0 | 24 | 52.0 | 53 | 5 | 7 | 45 | 1.15 | 20.7 | 3.2 |
| 124 | Brian Duensing | MIN | 5 | 2 | 3.64 | 24 | 9 | 0 | 84.0 | 84 | 7 | 31 | 53 | 1.37 | 14.8 | 8.6 |
| 125 | Ryan Dempster | CHC | 11 | 9 | 3.65 | 31 | 31 | 0 | 200.0 | 196 | 22 | 65 | 172 | 1.30 | 20.4 | 7.7 |
| 126 | Jeff Weaver | LAD | 6 | 4 | 3.65 | 28 | 7 | 0 | 79.0 | 87 | 7 | 33 | 64 | 1.52 | 18.0 | 9.3 |
| 127 | Daniel Bard | BOS | 2 | 2 | 3.65 | 49 | 0 | 1 | 49.3 | 41 | 5 | 22 | 63 | 1.28 | 29.7 | 10.4 |
| 128 | Mark DiFelice | MIL | 4 | 1 | 3.66 | 59 | 0 | 0 | 51.7 | 49 | 6 | 15 | 48 | 1.24 | 21.9 | 6.8 |
| 129 | Marc Rzepczynski | TOR | 2 | 4 | 3.67 | 11 | 11 | 0 | 61.3 | 51 | 7 | 30 | 60 | 1.32 | 23.0 | 11.5 |
| 130 | Kevin Millwood | TEX | 13 | 10 | 3.67 | 31 | 31 | 0 | 198.7 | 195 | 26 | 71 | 123 | 1.34 | 14.5 | 8.4 |
| 131 | Wade LeBlanc | SD | 3 | 1 | 3.69 | 9 | 9 | 0 | 46.3 | 35 | 6 | 19 | 30 | 1.17 | 15.5 | 9.8 |
| 132 | Francisco Rodriguez | NYM | 3 | 6 | 3.71 | 70 | 0 | 35 | 68.0 | 51 | 7 | 38 | 73 | 1.31 | 24.7 | 12.9 |
| 133 | Bobby Jenks | CWS | 3 | 4 | 3.71 | 52 | 0 | 29 | 53.3 | 52 | 9 | 16 | 49 | 1.27 | 21.5 | 7.0 |
| 134 | Yovani Gallardo | MIL | 13 | 12 | 3.73 | 30 | 30 | 0 | 185.7 | 150 | 21 | 94 | 204 | 1.31 | 25.7 | 11.9 |
| 135 | Ryan Rowland-Smith | SEA | 5 | 4 | 3.74 | 15 | 15 | 0 | 96.3 | 87 | 9 | 27 | 52 | 1.18 | 13.0 | 6.7 |
| 136 | Josh Fogg | COL | 0 | 2 | 3.74 | 24 | 1 | 0 | 45.7 | 32 | 7 | 20 | 27 | 1.14 | 14.4 | 10.7 |
| 137 | Burke Badenhop | FLO | 7 | 4 | 3.75 | 35 | 2 | 0 | 72.0 | 71 | 5 | 24 | 57 | 1.32 | 18.8 | 7.9 |
| 138 | Jered Weaver | LAA | 16 | 8 | 3.75 | 33 | 33 | 0 | 211.0 | 196 | 26 | 66 | 174 | 1.24 | 19.7 | 7.5 |
| 139 | Hiroki Kuroda | LAD | 8 | 7 | 3.76 | 21 | 20 | 0 | 117.3 | 110 | 12 | 24 | 87 | 1.14 | 17.9 | 4.9 |
| 140 | D. J. Carrasco | CWS | 5 | 1 | 3.76 | 49 | 1 | 0 | 93.3 | 103 | 5 | 29 | 62 | 1.41 | 15.3 | 7.2 |
| 141 | Brett Tomko | OAK | 5 | 3 | 3.77 | 21 | 6 | 0 | 57.3 | 50 | 12 | 13 | 33 | 1.10 | 14.5 | 5.7 |
| 142 | Carlos Zambrano | CHC | 9 | 7 | 3.77 | 28 | 28 | 0 | 169.3 | 155 | 10 | 78 | 152 | 1.38 | 20.7 | 10.6 |
| 143 | John Danks | CWS | 13 | 11 | 3.77 | 32 | 32 | 0 | 200.3 | 184 | 28 | 73 | 149 | 1.28 | 17.8 | 8.7 |
| 144 | Jarrod Washburn | DET | 9 | 9 | 3.78 | 28 | 28 | 0 | 176.0 | 160 | 23 | 49 | 100 | 1.19 | 13.8 | 6.8 |
| 145 | Ryan Perry | DET | 0 | 1 | 3.79 | 53 | 0 | 0 | 61.7 | 56 | 7 | 38 | 60 | 1.52 | 22.0 | 13.9 |
| 146 | John Lackey | LAA | 11 | 8 | 3.83 | 27 | 27 | 0 | 176.3 | 177 | 17 | 47 | 139 | 1.27 | 18.6 | 6.3 |
| 147 | Chris Narveson | MIL | 2 | 0 | 3.83 | 21 | 4 | 0 | 47.0 | 45 | 7 | 16 | 46 | 1.30 | 22.4 | 7.8 |
| 148 | Frank Francisco | TEX | 2 | 3 | 3.83 | 51 | 0 | 25 | 49.3 | 40 | 6 | 15 | 57 | 1.11 | 28.1 | 7.4 |
| 149 | Mark Buehrle | CWS | 13 | 10 | 3.84 | 33 | 33 | 0 | 213.3 | 222 | 27 | 45 | 105 | 1.25 | 12.0 | 5.1 |
| 150 | Bronson Arroyo | CIN | 15 | 13 | 3.84 | 33 | 33 | 0 | 220.3 | 214 | 31 | 65 | 127 | 1.27 | 13.8 | 7.0 |
| 151 | Kenshin Kawakami | ATL | 7 | 12 | 3.86 | 32 | 25 | 1 | 156.3 | 153 | 15 | 57 | 105 | 1.34 | 15.7 | 8.5 |
| 152 | Josh Beckett | BOS | 17 | 6 | 3.86 | 32 | 32 | 0 | 212.3 | 198 | 25 | 55 | 199 | 1.19 | 22.5 | 6.2 |
| 153 | Anibal Sanchez | FLO | 4 | 8 | 3.87 | 16 | 16 | 0 | 86.0 | 84 | 10 | 46 | 71 | 1.51 | 18.5 | 12.0 |
| 154 | Dustin Nippert | TEX | 5 | 3 | 3.88 | 20 | 10 | 0 | 69.7 | 64 | 7 | 29 | 54 | 1.33 | 18.0 | 9.7 |
| 155 | John Lannan | WSH | 9 | 13 | 3.88 | 33 | 33 | 0 | 206.3 | 210 | 22 | 68 | 89 | 1.35 | 10.2 | 7.8 |
| 156 | Dallas Braden | OAK | 8 | 9 | 3.89 | 22 | 22 | 0 | 136.7 | 144 | 9 | 42 | 81 | 1.36 | 13.8 | 7.1 |
| 157 | Kevin Correia | SD | 12 | 11 | 3.91 | 33 | 33 | 0 | 198.0 | 194 | 17 | 64 | 142 | 1.30 | 17.1 | 7.7 |
| 158 | David Weathers | MIL | 4 | 6 | 3.92 | 68 | 0 | 1 | 62.0 | 53 | 10 | 28 | 37 | 1.31 | 13.9 | 10.5 |
| 159 | Ross Ohlendorf | PIT | 11 | 10 | 3.92 | 29 | 29 | 0 | 176.7 | 165 | 25 | 53 | 109 | 1.23 | 15.0 | 7.3 |
| 160 | Brian Fuentes | LAA | 1 | 5 | 3.93 | 65 | 0 | 48 | 55.0 | 53 | 6 | 24 | 46 | 1.40 | 19.0 | 9.9 |
| 161 | Matt Palmer | LAA | 11 | 2 | 3.93 | 40 | 13 | 0 | 121.3 | 105 | 12 | 55 | 69 | 1.32 | 13.7 | 10.9 |
| 162 | Jeff Niemann | TB | 13 | 6 | 3.94 | 31 | 30 | 0 | 180.7 | 185 | 17 | 59 | 125 | 1.35 | 16.3 | 7.7 |
| 163 | Edward Mujica | SD | 3 | 5 | 3.94 | 67 | 4 | 2 | 93.7 | 101 | 14 | 19 | 76 | 1.28 | 19.3 | 4.8 |
| 164 | Matt Garza | TB | 8 | 12 | 3.95 | 32 | 32 | 0 | 203.0 | 177 | 25 | 79 | 189 | 1.26 | 22.0 | 9.2 |
| 165 | Rick Porcello | DET | 14 | 9 | 3.96 | 31 | 31 | 0 | 170.7 | 176 | 23 | 52 | 89 | 1.34 | 12.4 | 7.2 |
| 166 | Brian Stokes | NYM | 2 | 4 | 3.97 | 69 | 0 | 0 | 70.3 | 72 | 6 | 38 | 45 | 1.56 | 14.2 | 12.0 |
| 167 | Tony Peña | CWS | 6 | 5 | 3.99 | 72 | 0 | 2 | 70.0 | 81 | 7 | 20 | 55 | 1.44 | 17.6 | 6.4 |
| 168 | Cla Meredith | BAL | 4 | 2 | 3.99 | 64 | 0 | 0 | 65.3 | 73 | 4 | 25 | 37 | 1.50 | 13.1 | 8.8 |
| 169 | James McDonald | LAD | 5 | 5 | 4.00 | 45 | 4 | 0 | 63.0 | 60 | 6 | 34 | 54 | 1.49 | 19.3 | 12.1 |
| 170 | Jesse Chavez | PIT | 1 | 4 | 4.01 | 73 | 0 | 0 | 67.3 | 69 | 11 | 22 | 47 | 1.35 | 16.4 | 7.7 |
| 171 | Jon Garland | LAD | 11 | 13 | 4.01 | 33 | 33 | 0 | 204.0 | 225 | 23 | 61 | 109 | 1.40 | 12.4 | 6.9 |
| 172 | Joe Nelson | TB | 3 | 0 | 4.02 | 42 | 0 | 3 | 40.3 | 32 | 7 | 27 | 36 | 1.46 | 19.8 | 14.8 |
| 173 | Danys Baez | BAL | 4 | 6 | 4.02 | 59 | 0 | 0 | 71.7 | 59 | 8 | 22 | 40 | 1.13 | 13.6 | 7.5 |
| 174 | Nick Blackburn | MIN | 11 | 11 | 4.03 | 33 | 33 | 0 | 205.7 | 240 | 25 | 41 | 98 | 1.37 | 11.1 | 4.6 |
| 175 | Barry Zito | SF | 10 | 13 | 4.03 | 33 | 33 | 0 | 192.0 | 179 | 21 | 81 | 154 | 1.35 | 18.8 | 9.9 |
| 176 | Chad Billingsley | LAD | 12 | 11 | 4.03 | 33 | 32 | 0 | 196.3 | 173 | 17 | 86 | 179 | 1.32 | 21.7 | 10.4 |
| 177 | Miguel Batista | SEA | 7 | 4 | 4.04 | 56 | 0 | 1 | 71.3 | 79 | 7 | 39 | 52 | 1.65 | 16.0 | 12.0 |
| 178 | Jason Marquis | COL | 15 | 13 | 4.04 | 33 | 33 | 0 | 216.0 | 218 | 15 | 80 | 115 | 1.38 | 12.5 | 8.7 |
| 179 | A. J. Burnett | NYY | 13 | 9 | 4.04 | 33 | 33 | 0 | 207.0 | 193 | 25 | 97 | 195 | 1.40 | 21.8 | 10.8 |
| 180 | Koji Uehara | BAL | 2 | 4 | 4.05 | 12 | 12 | 0 | 66.7 | 71 | 7 | 12 | 48 | 1.24 | 17.2 | 4.3 |
| 181 | Joe Blanton | PHI | 12 | 8 | 4.05 | 31 | 31 | 0 | 195.3 | 198 | 30 | 59 | 163 | 1.32 | 19.5 | 7.0 |
| 182 | Brett Anderson | OAK | 11 | 11 | 4.06 | 30 | 30 | 0 | 175.3 | 180 | 20 | 45 | 150 | 1.28 | 20.4 | 6.1 |
| 183 | J. C. Gutierrez | ARI | 4 | 3 | 4.06 | 65 | 0 | 9 | 71.0 | 67 | 2 | 30 | 66 | 1.37 | 21.5 | 9.8 |
| 184 | Zach Duke | PIT | 11 | 16 | 4.06 | 32 | 32 | 0 | 213.0 | 231 | 23 | 49 | 106 | 1.31 | 11.9 | 5.5 |
| 185 | Gavin Floyd | CWS | 11 | 11 | 4.06 | 30 | 30 | 0 | 193.0 | 178 | 21 | 59 | 163 | 1.23 | 20.5 | 7.4 |
| 186 | Juan Carlos Oviedo | FLO | 4 | 6 | 4.06 | 75 | 0 | 26 | 68.7 | 59 | 13 | 27 | 60 | 1.25 | 20.5 | 9.2 |
| 187 | Scott Feldman | TEX | 17 | 8 | 4.08 | 34 | 31 | 0 | 189.7 | 178 | 18 | 65 | 113 | 1.28 | 14.3 | 8.2 |
| 188 | Rich Harden | CHC | 9 | 9 | 4.09 | 26 | 26 | 0 | 141.0 | 122 | 23 | 67 | 171 | 1.34 | 28.1 | 11.0 |
| 189 | Nelson Figueroa | NYM | 3 | 8 | 4.09 | 16 | 10 | 0 | 70.3 | 80 | 8 | 24 | 59 | 1.48 | 18.4 | 7.5 |
| 190 | Tommy Hunter | TEX | 9 | 6 | 4.10 | 19 | 19 | 0 | 112.0 | 113 | 13 | 33 | 64 | 1.30 | 13.5 | 6.9 |
| 191 | Russ Springer | TB | 1 | 4 | 4.11 | 74 | 0 | 1 | 57.0 | 68 | 9 | 17 | 58 | 1.49 | 22.7 | 6.6 |
| 192 | Aaron Heilman | CHC | 4 | 4 | 4.11 | 70 | 0 | 1 | 72.3 | 68 | 9 | 34 | 65 | 1.41 | 20.8 | 10.9 |
| 193 | Chris Smith | MIL | 0 | 0 | 4.11 | 35 | 0 | 0 | 46.0 | 41 | 11 | 19 | 35 | 1.30 | 17.5 | 9.5 |
| 194 | Jim Johnson | BAL | 4 | 6 | 4.11 | 64 | 0 | 10 | 70.0 | 73 | 8 | 23 | 49 | 1.37 | 16.3 | 7.7 |
| 195 | Blaine Boyer | ARI | 0 | 2 | 4.12 | 48 | 0 | 0 | 54.7 | 56 | 1 | 20 | 29 | 1.39 | 12.0 | 8.3 |
| 196 | Doug Davis | ARI | 9 | 14 | 4.12 | 34 | 34 | 0 | 203.3 | 203 | 25 | 103 | 146 | 1.50 | 16.4 | 11.6 |
| 197 | Roy Oswalt | HOU | 8 | 6 | 4.12 | 30 | 30 | 0 | 181.3 | 183 | 19 | 42 | 138 | 1.24 | 18.2 | 5.5 |
| 198 | Max Scherzer | ARI | 9 | 11 | 4.12 | 30 | 30 | 0 | 170.3 | 166 | 20 | 63 | 174 | 1.34 | 23.5 | 8.5 |
| 199 | Doug Fister | SEA | 3 | 4 | 4.13 | 11 | 10 | 0 | 61.0 | 63 | 11 | 15 | 36 | 1.28 | 14.1 | 5.9 |
| 200 | Jason Jennings | TEX | 2 | 4 | 4.13 | 44 | 0 | 1 | 61.0 | 67 | 7 | 28 | 44 | 1.56 | 16.2 | 10.3 |
| 201 | James Shields | TB | 11 | 12 | 4.14 | 33 | 33 | 0 | 219.7 | 239 | 29 | 52 | 167 | 1.32 | 18.0 | 5.6 |
| 202 | Greg Burke | SD | 3 | 3 | 4.14 | 48 | 0 | 0 | 45.7 | 48 | 4 | 23 | 33 | 1.55 | 16.2 | 11.3 |
| 203 | Aaron Cook | COL | 11 | 6 | 4.16 | 27 | 27 | 0 | 158.0 | 175 | 19 | 47 | 78 | 1.41 | 11.6 | 7.0 |
| 204 | Andy Pettitte | NYY | 14 | 8 | 4.16 | 32 | 32 | 0 | 194.7 | 193 | 20 | 76 | 148 | 1.38 | 17.7 | 9.1 |
| 205 | Bartolo Colon | CWS | 3 | 6 | 4.19 | 12 | 12 | 0 | 62.3 | 69 | 13 | 21 | 38 | 1.44 | 13.8 | 7.6 |
| 206 | Mitchell Boggs | STL | 2 | 3 | 4.19 | 16 | 9 | 0 | 58.0 | 71 | 3 | 33 | 46 | 1.79 | 17.2 | 12.3 |
| 207 | Clay Buchholz | BOS | 7 | 4 | 4.21 | 16 | 16 | 0 | 92.0 | 91 | 13 | 36 | 68 | 1.38 | 17.0 | 9.0 |
| 208 | Aaron Harang | CIN | 6 | 14 | 4.21 | 26 | 26 | 0 | 162.3 | 186 | 24 | 43 | 142 | 1.41 | 20.2 | 6.1 |
| 209 | Matt Daley | COL | 1 | 1 | 4.24 | 57 | 0 | 0 | 51.0 | 43 | 6 | 18 | 55 | 1.20 | 26.1 | 8.5 |
| 210 | Jonathan Sanchez | SF | 8 | 12 | 4.24 | 32 | 29 | 0 | 163.3 | 135 | 19 | 88 | 177 | 1.37 | 24.9 | 12.4 |
| 211 | Ron Villone | WSH | 5 | 6 | 4.25 | 63 | 0 | 1 | 48.7 | 54 | 6 | 29 | 33 | 1.71 | 14.5 | 12.7 |
| 212 | Bobby Seay | DET | 6 | 3 | 4.25 | 67 | 0 | 0 | 48.7 | 46 | 3 | 17 | 37 | 1.29 | 17.8 | 8.2 |
| 213 | Kerry Wood | CLE | 3 | 3 | 4.25 | 58 | 0 | 20 | 55.0 | 48 | 7 | 28 | 63 | 1.38 | 26.1 | 11.6 |
| 214 | Kris Medlen | ATL | 3 | 5 | 4.26 | 37 | 4 | 0 | 67.7 | 65 | 5 | 30 | 72 | 1.40 | 24.5 | 10.2 |
| 215 | Chris Perez | CLE | 1 | 2 | 4.26 | 61 | 0 | 2 | 57.0 | 41 | 8 | 27 | 68 | 1.19 | 28.5 | 11.3 |
| 216 | Zach Miner | DET | 7 | 5 | 4.29 | 51 | 5 | 1 | 92.3 | 101 | 11 | 45 | 62 | 1.58 | 15.2 | 11.0 |
| 217 | Ron Mahay | MIN | 2 | 1 | 4.29 | 57 | 0 | 0 | 50.3 | 62 | 10 | 22 | 42 | 1.67 | 17.6 | 9.2 |
| 218 | Rick van den Hurk | FLO | 3 | 2 | 4.30 | 11 | 11 | 0 | 58.7 | 57 | 11 | 21 | 49 | 1.33 | 19.1 | 8.2 |
| 219 | Ricky Romero | TOR | 13 | 9 | 4.30 | 29 | 29 | 0 | 178.0 | 192 | 18 | 79 | 141 | 1.52 | 18.3 | 10.2 |
| 220 | Mike MacDougal | WSH | 1 | 1 | 4.31 | 57 | 0 | 20 | 54.3 | 52 | 3 | 38 | 34 | 1.66 | 13.8 | 15.4 |
| 221 | Cole Hamels | PHI | 10 | 11 | 4.32 | 32 | 32 | 0 | 193.7 | 206 | 24 | 43 | 168 | 1.29 | 20.6 | 5.3 |
| 222 | Sean Marshall | CHC | 3 | 7 | 4.32 | 55 | 9 | 0 | 85.3 | 91 | 10 | 32 | 68 | 1.44 | 18.2 | 8.6 |
| 223 | Jamey Wright | KC | 3 | 5 | 4.33 | 65 | 0 | 0 | 79.0 | 73 | 8 | 44 | 60 | 1.48 | 17.1 | 12.6 |
| 224 | Jason Hammel | COL | 10 | 8 | 4.33 | 34 | 30 | 0 | 176.7 | 203 | 17 | 42 | 133 | 1.39 | 17.3 | 5.4 |
| 225 | Freddy Garcia | CWS | 3 | 4 | 4.34 | 9 | 9 | 0 | 56.0 | 56 | 4 | 12 | 37 | 1.21 | 16.2 | 5.2 |
| 226 | Edinson Volquez | CIN | 4 | 2 | 4.35 | 9 | 9 | 0 | 49.7 | 34 | 6 | 32 | 47 | 1.33 | 21.6 | 14.7 |
| 227 | Scott Baker | MIN | 15 | 9 | 4.37 | 33 | 33 | 0 | 200.0 | 190 | 28 | 48 | 162 | 1.19 | 19.6 | 5.8 |
| 228 | Mark Hendrickson | BAL | 6 | 5 | 4.37 | 53 | 11 | 1 | 105.0 | 116 | 16 | 33 | 61 | 1.42 | 13.3 | 7.2 |
| 229 | Jorge De La Rosa | COL | 16 | 9 | 4.38 | 33 | 32 | 0 | 185.0 | 172 | 20 | 83 | 193 | 1.38 | 24.2 | 10.4 |
| 230 | Chad Durbin | PHI | 2 | 2 | 4.39 | 59 | 0 | 2 | 69.7 | 56 | 8 | 47 | 62 | 1.48 | 19.7 | 15.0 |
| 231 | Brandon Morrow | SEA | 2 | 4 | 4.39 | 26 | 10 | 6 | 69.7 | 66 | 10 | 44 | 63 | 1.58 | 20.1 | 14.1 |
| 232 | Jared Burton | CIN | 1 | 0 | 4.40 | 53 | 0 | 0 | 59.3 | 61 | 5 | 23 | 45 | 1.42 | 17.0 | 8.7 |
| 233 | Fernando Rodney | DET | 2 | 5 | 4.40 | 73 | 0 | 37 | 75.7 | 70 | 8 | 41 | 61 | 1.47 | 18.5 | 12.4 |
| 234 | Clayton Richard | SD | 9 | 5 | 4.41 | 38 | 26 | 0 | 153.0 | 154 | 17 | 71 | 114 | 1.47 | 17.2 | 10.7 |
| 235 | Johnny Cueto | CIN | 11 | 11 | 4.41 | 30 | 30 | 0 | 171.3 | 172 | 24 | 61 | 132 | 1.36 | 17.8 | 8.2 |
| 236 | Esmerling Vasquez | ARI | 3 | 3 | 4.42 | 53 | 0 | 0 | 53.0 | 52 | 4 | 29 | 45 | 1.53 | 18.9 | 12.2 |
| 237 | David Price | TB | 10 | 7 | 4.42 | 23 | 23 | 0 | 128.3 | 119 | 17 | 54 | 102 | 1.35 | 18.3 | 9.7 |
| 238 | John Maine | NYM | 7 | 6 | 4.43 | 15 | 15 | 0 | 81.3 | 67 | 8 | 38 | 55 | 1.29 | 15.8 | 10.9 |
| 239 | Chan Ho Park | PHI | 3 | 3 | 4.43 | 45 | 7 | 0 | 83.3 | 84 | 5 | 33 | 73 | 1.40 | 20.2 | 9.1 |
| 240 | Paul Maholm | PIT | 8 | 9 | 4.44 | 31 | 31 | 0 | 194.7 | 221 | 14 | 60 | 119 | 1.44 | 14.2 | 7.2 |
| 241 | Aaron Laffey | CLE | 7 | 9 | 4.44 | 25 | 19 | 1 | 121.7 | 140 | 9 | 57 | 59 | 1.62 | 10.9 | 10.6 |
| 242 | J. D. Martin | WSH | 5 | 4 | 4.44 | 15 | 15 | 0 | 77.0 | 85 | 14 | 24 | 37 | 1.42 | 10.9 | 7.0 |
| 243 | Vicente Padilla | LAD | 12 | 6 | 4.46 | 26 | 25 | 0 | 147.3 | 156 | 16 | 54 | 97 | 1.43 | 15.3 | 8.5 |
| 244 | Carlos Fisher | CIN | 1 | 1 | 4.47 | 39 | 0 | 0 | 52.3 | 50 | 4 | 31 | 48 | 1.55 | 21.2 | 13.7 |
| 245 | Pat Misch | NYM | 3 | 4 | 4.48 | 26 | 7 | 0 | 62.3 | 68 | 9 | 22 | 23 | 1.44 | 8.5 | 8.1 |
| 246 | Franklin Morales | COL | 3 | 2 | 4.50 | 40 | 2 | 7 | 40.0 | 38 | 4 | 23 | 41 | 1.52 | 22.9 | 12.8 |
| 247 | Jason Bergmann | WSH | 2 | 4 | 4.50 | 56 | 0 | 0 | 48.0 | 50 | 7 | 25 | 40 | 1.56 | 18.8 | 11.7 |
| 248 | Shawn Kelley | SEA | 5 | 4 | 4.50 | 41 | 0 | 0 | 46.0 | 45 | 9 | 9 | 41 | 1.17 | 21.5 | 4.7 |
| 249 | Phil Coke | NYY | 4 | 3 | 4.50 | 72 | 0 | 2 | 60.0 | 44 | 10 | 20 | 49 | 1.07 | 20.6 | 8.4 |
| 250 | Sean Green | NYM | 1 | 4 | 4.52 | 79 | 0 | 1 | 69.7 | 64 | 5 | 36 | 54 | 1.44 | 17.1 | 11.4 |
| 251 | Justin Masterson | CLE | 4 | 10 | 4.52 | 42 | 16 | 0 | 129.3 | 128 | 12 | 60 | 119 | 1.45 | 21.0 | 10.6 |
| 252 | Manny Delcarmen | BOS | 5 | 2 | 4.53 | 64 | 0 | 0 | 59.7 | 64 | 5 | 34 | 44 | 1.64 | 15.8 | 12.2 |
| 253 | Homer Bailey | CIN | 8 | 5 | 4.53 | 20 | 20 | 0 | 113.3 | 115 | 12 | 52 | 86 | 1.47 | 17.3 | 10.5 |
| 254 | Bud Norris | HOU | 6 | 3 | 4.53 | 11 | 10 | 0 | 55.7 | 59 | 9 | 25 | 54 | 1.51 | 21.7 | 10.0 |
| 255 | Charlie Morton | PIT | 5 | 9 | 4.55 | 18 | 18 | 0 | 97.0 | 102 | 7 | 40 | 62 | 1.46 | 14.9 | 9.6 |
| 256 | Brandon League | TOR | 3 | 6 | 4.58 | 67 | 0 | 0 | 74.7 | 72 | 8 | 21 | 76 | 1.25 | 24.3 | 6.7 |
| 257 | Tim Wakefield | BOS | 11 | 5 | 4.58 | 21 | 21 | 0 | 129.7 | 137 | 12 | 50 | 72 | 1.44 | 12.6 | 8.7 |
| 258 | Joe Saunders | LAA | 16 | 7 | 4.60 | 31 | 31 | 0 | 186.0 | 202 | 29 | 64 | 101 | 1.43 | 12.5 | 8.0 |
| 259 | Jensen Lewis | CLE | 2 | 4 | 4.61 | 47 | 0 | 1 | 66.3 | 62 | 13 | 29 | 62 | 1.37 | 21.8 | 10.2 |
| 260 | R. A. Dickey | MIN | 1 | 1 | 4.62 | 35 | 1 | 0 | 64.3 | 74 | 8 | 30 | 42 | 1.62 | 14.3 | 10.2 |
| 261 | Mat Latos | SD | 4 | 5 | 4.62 | 10 | 10 | 0 | 50.7 | 43 | 7 | 23 | 39 | 1.30 | 18.4 | 10.8 |
| 262 | Brandon McCarthy | TEX | 7 | 4 | 4.62 | 17 | 17 | 0 | 97.3 | 96 | 13 | 36 | 65 | 1.36 | 15.5 | 8.6 |
| 263 | Jordan Zimmermann | WSH | 3 | 5 | 4.63 | 16 | 16 | 0 | 91.3 | 95 | 10 | 29 | 92 | 1.36 | 23.5 | 7.4 |
| 264 | Trevor Cahill | OAK | 10 | 13 | 4.63 | 32 | 32 | 0 | 178.7 | 185 | 27 | 72 | 90 | 1.44 | 11.6 | 9.3 |
| 265 | Brian Matusz | BAL | 5 | 2 | 4.63 | 8 | 8 | 0 | 44.7 | 52 | 6 | 14 | 38 | 1.48 | 19.4 | 7.1 |
| 266 | Chad Gaudin | NYY | 6 | 10 | 4.64 | 31 | 25 | 0 | 147.3 | 146 | 14 | 76 | 139 | 1.51 | 20.9 | 11.4 |
| 267 | Jesse Carlson | TOR | 1 | 6 | 4.66 | 73 | 0 | 0 | 67.7 | 67 | 7 | 21 | 51 | 1.30 | 17.5 | 7.2 |
| 268 | Scott Linebrink | CWS | 3 | 7 | 4.66 | 57 | 0 | 2 | 56.0 | 70 | 9 | 23 | 55 | 1.66 | 21.2 | 8.9 |
| 269 | Derek Lowe | ATL | 15 | 10 | 4.67 | 34 | 34 | 0 | 194.7 | 232 | 16 | 63 | 111 | 1.52 | 13.0 | 7.4 |
| 270 | Jesse Crain | MIN | 7 | 4 | 4.70 | 56 | 0 | 0 | 51.7 | 48 | 3 | 27 | 43 | 1.45 | 18.7 | 11.7 |
| 271 | Kevin Gregg | CHC | 5 | 6 | 4.72 | 72 | 0 | 23 | 68.7 | 60 | 13 | 30 | 71 | 1.31 | 23.8 | 10.1 |
| 272 | Brian Bannister | KC | 7 | 12 | 4.73 | 26 | 26 | 0 | 154.0 | 161 | 15 | 50 | 98 | 1.37 | 14.7 | 7.5 |
| 273 | Kyle Lohse | STL | 6 | 10 | 4.74 | 23 | 22 | 0 | 117.7 | 125 | 16 | 36 | 77 | 1.37 | 15.0 | 7.0 |
| 274 | Joba Chamberlain | NYY | 9 | 6 | 4.75 | 32 | 31 | 0 | 157.3 | 167 | 21 | 76 | 133 | 1.54 | 18.8 | 10.7 |
| 275 | Leo Rosales | ARI | 2 | 1 | 4.76 | 33 | 0 | 0 | 45.3 | 40 | 5 | 12 | 31 | 1.15 | 16.7 | 6.5 |
| 276 | Jason Motte | STL | 4 | 4 | 4.76 | 69 | 0 | 0 | 56.7 | 57 | 10 | 23 | 54 | 1.41 | 22.1 | 9.4 |
| 277 | Joel Hanrahan | PIT | 1 | 4 | 4.78 | 67 | 0 | 5 | 64.0 | 73 | 3 | 34 | 72 | 1.67 | 24.2 | 11.4 |
| 278 | Sean West | FLO | 8 | 6 | 4.79 | 20 | 20 | 0 | 103.3 | 115 | 11 | 44 | 70 | 1.54 | 15.0 | 9.4 |
| 279 | Luis Perdomo | SD | 1 | 0 | 4.80 | 35 | 0 | 0 | 60.0 | 57 | 11 | 34 | 55 | 1.52 | 20.5 | 12.7 |
| 280 | Grant Balfour | TB | 5 | 4 | 4.81 | 73 | 0 | 4 | 67.3 | 59 | 6 | 33 | 69 | 1.37 | 23.9 | 11.4 |
| 281 | Roman Colon | KC | 2 | 3 | 4.83 | 43 | 0 | 0 | 50.3 | 50 | 7 | 22 | 29 | 1.43 | 13.2 | 10.0 |
| 282 | Bobby Keppel | MIN | 1 | 1 | 4.83 | 37 | 0 | 0 | 54.0 | 63 | 4 | 21 | 32 | 1.56 | 13.2 | 8.7 |
| 283 | Brad Thompson | STL | 2 | 6 | 4.84 | 32 | 8 | 0 | 80.0 | 85 | 8 | 23 | 34 | 1.35 | 9.9 | 6.7 |
| 284 | Andrew Miller | FLO | 3 | 5 | 4.84 | 20 | 14 | 0 | 80.0 | 85 | 7 | 43 | 59 | 1.60 | 16.1 | 11.7 |
| 285 | Brett Myers | PHI | 4 | 3 | 4.84 | 18 | 10 | 0 | 70.7 | 74 | 18 | 23 | 50 | 1.37 | 16.4 | 7.6 |
| 286 | Ian Snell | SEA | 7 | 10 | 4.84 | 27 | 27 | 0 | 145.0 | 148 | 14 | 83 | 89 | 1.59 | 13.7 | 12.8 |
| 287 | Eric Stults | LAD | 4 | 3 | 4.86 | 10 | 10 | 0 | 50.0 | 51 | 3 | 26 | 33 | 1.54 | 14.8 | 11.7 |
| 288 | Kevin Slowey | MIN | 10 | 3 | 4.86 | 16 | 16 | 0 | 90.7 | 113 | 15 | 15 | 75 | 1.41 | 19.0 | 3.8 |
| 289 | Matt Maloney | CIN | 2 | 4 | 4.87 | 7 | 7 | 0 | 40.7 | 43 | 9 | 8 | 28 | 1.25 | 16.5 | 4.7 |
| 290 | Randy Johnson | SF | 8 | 6 | 4.88 | 22 | 17 | 0 | 96.0 | 97 | 19 | 31 | 86 | 1.33 | 20.9 | 7.5 |
| 291 | Brad Penny | SF | 11 | 9 | 4.88 | 30 | 30 | 0 | 173.3 | 191 | 22 | 51 | 109 | 1.40 | 14.5 | 6.8 |
| 292 | Scott Kazmir | LAA | 10 | 9 | 4.89 | 26 | 26 | 0 | 147.3 | 149 | 16 | 60 | 117 | 1.42 | 18.1 | 9.3 |
| 293 | Brian Bass | BAL | 5 | 3 | 4.90 | 48 | 0 | 0 | 86.3 | 106 | 11 | 44 | 54 | 1.74 | 13.5 | 11.0 |
| 294 | Jason Vargas | SEA | 3 | 6 | 4.91 | 23 | 14 | 0 | 91.7 | 98 | 16 | 24 | 54 | 1.33 | 14.0 | 6.2 |
| 295 | Jose Contreras | COL | 6 | 13 | 4.92 | 28 | 23 | 0 | 131.7 | 141 | 13 | 53 | 106 | 1.47 | 18.0 | 9.0 |
| 296 | Seth McClung | MIL | 3 | 3 | 4.94 | 41 | 2 | 0 | 62.0 | 62 | 11 | 39 | 40 | 1.63 | 14.4 | 14.0 |
| 297 | Kevin Jepsen | LAA | 6 | 4 | 4.94 | 54 | 0 | 1 | 54.7 | 63 | 2 | 19 | 48 | 1.50 | 20.3 | 8.0 |
| 298 | Jamie Moyer | PHI | 12 | 10 | 4.94 | 30 | 25 | 0 | 162.0 | 177 | 27 | 43 | 94 | 1.36 | 13.4 | 6.2 |
| 299 | Ross Detwiler | WSH | 1 | 6 | 5.00 | 15 | 14 | 0 | 75.7 | 87 | 3 | 33 | 43 | 1.59 | 12.6 | 9.7 |
| 300 | Jeff Bennett | TB | 2 | 4 | 5.01 | 44 | 0 | 0 | 46.7 | 66 | 4 | 32 | 27 | 2.10 | 11.6 | 13.7 |
| 301 | Ervin Santana | LAA | 8 | 8 | 5.03 | 24 | 23 | 0 | 139.7 | 159 | 24 | 47 | 107 | 1.47 | 17.4 | 7.7 |
| 302 | Mike Pelfrey | NYM | 10 | 12 | 5.03 | 31 | 31 | 0 | 184.3 | 213 | 18 | 66 | 107 | 1.51 | 13.0 | 8.0 |
| 303 | Jeremy Guthrie | BAL | 10 | 17 | 5.04 | 33 | 33 | 0 | 200.0 | 224 | 35 | 60 | 110 | 1.42 | 12.6 | 6.9 |
| 304 | Chris Sampson | HOU | 4 | 2 | 5.04 | 49 | 0 | 3 | 55.3 | 66 | 2 | 21 | 33 | 1.57 | 13.3 | 8.5 |
| 305 | Ricky Nolasco | FLO | 13 | 9 | 5.06 | 31 | 31 | 0 | 185.0 | 188 | 23 | 44 | 195 | 1.25 | 24.8 | 5.6 |
| 306 | Gil Meche | KC | 6 | 10 | 5.09 | 23 | 23 | 0 | 129.0 | 144 | 17 | 58 | 95 | 1.57 | 16.4 | 10.0 |
| 307 | Tim Redding | NYM | 3 | 6 | 5.10 | 30 | 17 | 0 | 120.0 | 122 | 18 | 50 | 76 | 1.43 | 14.5 | 9.5 |
| 308 | Carl Pavano | MIN | 14 | 12 | 5.10 | 33 | 33 | 0 | 199.3 | 235 | 26 | 39 | 147 | 1.37 | 17.2 | 4.6 |
| 309 | Craig Stammen | WSH | 4 | 7 | 5.11 | 19 | 19 | 0 | 105.7 | 112 | 14 | 24 | 48 | 1.29 | 10.7 | 5.4 |
| 310 | Justin Speier | LAA | 4 | 2 | 5.17 | 41 | 0 | 0 | 40.0 | 44 | 7 | 15 | 39 | 1.48 | 21.4 | 8.2 |
| 311 | Jose Veras | CLE | 4 | 3 | 5.19 | 47 | 0 | 0 | 50.3 | 42 | 8 | 28 | 40 | 1.39 | 17.8 | 12.4 |
| 312 | Chris Volstad | FLO | 9 | 13 | 5.21 | 29 | 29 | 0 | 159.0 | 169 | 29 | 59 | 107 | 1.43 | 15.7 | 8.7 |
| 313 | Chris Young | SD | 4 | 6 | 5.21 | 14 | 14 | 0 | 76.0 | 70 | 12 | 40 | 50 | 1.45 | 14.9 | 11.9 |
| 314 | Luke French | SEA | 4 | 5 | 5.21 | 15 | 12 | 0 | 67.3 | 87 | 11 | 28 | 42 | 1.71 | 13.5 | 9.0 |
| 315 | Braden Looper | MIL | 14 | 7 | 5.22 | 34 | 34 | 0 | 194.7 | 226 | 39 | 64 | 100 | 1.49 | 11.5 | 7.4 |
| 316 | Shairon Martis | WSH | 5 | 3 | 5.25 | 15 | 15 | 0 | 85.7 | 83 | 11 | 39 | 34 | 1.42 | 9.0 | 10.3 |
| 317 | Jeremy Sowers | CLE | 6 | 11 | 5.25 | 23 | 22 | 0 | 123.3 | 134 | 11 | 52 | 51 | 1.51 | 9.4 | 9.5 |
| 318 | Kyle Davies | KC | 8 | 9 | 5.27 | 22 | 22 | 0 | 123.0 | 122 | 18 | 66 | 86 | 1.53 | 16.0 | 12.3 |
| 319 | Jeff Suppan | MIL | 7 | 12 | 5.29 | 30 | 30 | 0 | 161.7 | 200 | 25 | 74 | 80 | 1.69 | 10.7 | 9.9 |
| 320 | Bobby Parnell | NYM | 4 | 8 | 5.30 | 68 | 8 | 1 | 88.3 | 101 | 8 | 46 | 74 | 1.66 | 17.9 | 11.1 |
| 321 | Brett Cecil | TOR | 7 | 4 | 5.30 | 18 | 17 | 0 | 93.3 | 116 | 17 | 38 | 69 | 1.65 | 16.4 | 9.0 |
| 322 | Mike Hampton | HOU | 7 | 10 | 5.30 | 21 | 21 | 0 | 112.0 | 128 | 13 | 46 | 74 | 1.55 | 15.0 | 9.3 |
| 323 | Vin Mazzaro | OAK | 4 | 9 | 5.32 | 17 | 17 | 0 | 91.3 | 120 | 12 | 39 | 59 | 1.74 | 13.9 | 9.2 |
| 324 | Jason Grilli | TEX | 2 | 3 | 5.32 | 52 | 0 | 1 | 45.7 | 50 | 4 | 27 | 49 | 1.69 | 23.1 | 12.7 |
| 325 | Brian Tallet | TOR | 7 | 9 | 5.32 | 37 | 25 | 0 | 160.7 | 169 | 20 | 72 | 120 | 1.50 | 16.7 | 10.0 |
| 326 | Chris Jakubauskas | SEA | 6 | 7 | 5.32 | 35 | 8 | 0 | 93.0 | 91 | 15 | 27 | 47 | 1.27 | 12.1 | 6.9 |
| 327 | Kip Wells | CIN | 2 | 5 | 5.33 | 33 | 7 | 2 | 72.7 | 60 | 6 | 40 | 43 | 1.38 | 13.7 | 12.7 |
| 328 | Micah Owings | CIN | 7 | 12 | 5.34 | 26 | 19 | 1 | 119.7 | 126 | 18 | 64 | 68 | 1.59 | 12.5 | 11.8 |
| 329 | Carlos Villanueva | MIL | 4 | 10 | 5.34 | 64 | 6 | 3 | 96.0 | 102 | 13 | 35 | 83 | 1.43 | 19.7 | 8.3 |
| 330 | Justin Lehr | CIN | 5 | 3 | 5.37 | 11 | 11 | 0 | 65.3 | 72 | 14 | 28 | 33 | 1.53 | 11.5 | 9.8 |
| 331 | Chris Tillman | BAL | 2 | 5 | 5.40 | 12 | 12 | 0 | 65.0 | 77 | 15 | 24 | 39 | 1.55 | 13.7 | 8.4 |
| 332 | Jeff Karstens | PIT | 4 | 6 | 5.42 | 39 | 13 | 0 | 108.0 | 115 | 12 | 45 | 52 | 1.48 | 11.0 | 9.6 |
| 333 | David Hernandez | BAL | 4 | 10 | 5.42 | 20 | 19 | 0 | 101.3 | 118 | 27 | 46 | 68 | 1.62 | 14.7 | 10.0 |
| 334 | Nate Robertson | DET | 2 | 3 | 5.44 | 28 | 6 | 0 | 49.7 | 59 | 4 | 28 | 35 | 1.75 | 15.0 | 12.0 |
| 335 | Livan Hernandez | WSH | 9 | 12 | 5.44 | 31 | 31 | 0 | 183.7 | 220 | 19 | 67 | 102 | 1.56 | 12.7 | 8.3 |
| 336 | Wesley Wright | HOU | 3 | 4 | 5.44 | 49 | 0 | 0 | 44.7 | 53 | 9 | 25 | 47 | 1.75 | 23.0 | 12.3 |
| 337 | Kevin Hart | PIT | 4 | 9 | 5.44 | 18 | 14 | 0 | 81.0 | 97 | 11 | 44 | 52 | 1.74 | 13.9 | 11.8 |
| 338 | Brian Moehler | HOU | 8 | 12 | 5.47 | 29 | 29 | 0 | 154.7 | 187 | 21 | 51 | 91 | 1.54 | 13.1 | 7.3 |
| 339 | Matt Albers | BAL | 3 | 6 | 5.51 | 56 | 0 | 0 | 67.0 | 80 | 3 | 36 | 49 | 1.73 | 15.9 | 11.7 |
| 340 | Edgar Gonzalez | OAK | 0 | 4 | 5.51 | 26 | 6 | 0 | 65.3 | 76 | 4 | 28 | 39 | 1.59 | 13.0 | 9.4 |
| 341 | Scott Richmond | TOR | 8 | 11 | 5.52 | 27 | 24 | 0 | 138.7 | 147 | 27 | 59 | 117 | 1.49 | 19.2 | 9.7 |
| 342 | Tom Gorzelanny | CHC | 7 | 3 | 5.55 | 22 | 7 | 0 | 47.0 | 45 | 6 | 17 | 47 | 1.32 | 23.0 | 8.3 |
| 343 | Russ Ortiz | HOU | 3 | 6 | 5.57 | 23 | 13 | 0 | 85.7 | 95 | 8 | 48 | 65 | 1.67 | 16.8 | 12.4 |
| 344 | Garrett Olson | SEA | 3 | 5 | 5.60 | 31 | 11 | 0 | 80.3 | 79 | 19 | 34 | 47 | 1.41 | 13.5 | 9.8 |
| 345 | David Huff | CLE | 11 | 8 | 5.61 | 23 | 23 | 0 | 128.3 | 159 | 16 | 41 | 65 | 1.56 | 11.3 | 7.1 |
| 346 | Garrett Mock | WSH | 3 | 10 | 5.62 | 28 | 15 | 0 | 91.3 | 114 | 9 | 44 | 72 | 1.73 | 17.1 | 10.4 |
| 347 | Luis Ayala | FLO | 1 | 5 | 5.62 | 38 | 0 | 0 | 40.0 | 50 | 5 | 14 | 28 | 1.60 | 15.6 | 7.8 |
| 348 | Armando Galarraga | DET | 6 | 10 | 5.64 | 29 | 25 | 0 | 143.7 | 158 | 24 | 67 | 95 | 1.57 | 14.8 | 10.4 |
| 349 | Merkin Valdez | SF | 2 | 1 | 5.66 | 48 | 0 | 0 | 49.3 | 57 | 5 | 28 | 38 | 1.72 | 16.9 | 12.4 |
| 350 | Juan Cruz | KC | 3 | 4 | 5.72 | 46 | 0 | 2 | 50.3 | 46 | 6 | 29 | 38 | 1.49 | 17.4 | 13.2 |
| 351 | Gio Gonzalez | OAK | 6 | 7 | 5.75 | 20 | 17 | 0 | 98.7 | 113 | 14 | 56 | 109 | 1.71 | 24.0 | 12.3 |
| 352 | Mike Burns | MIL | 3 | 5 | 5.75 | 15 | 8 | 0 | 51.7 | 60 | 10 | 17 | 39 | 1.49 | 17.2 | 7.5 |
| 353 | Daisuke Matsuzaka | BOS | 4 | 6 | 5.76 | 12 | 12 | 0 | 59.3 | 81 | 10 | 30 | 54 | 1.87 | 19.1 | 10.6 |
| 354 | Bruce Chen | KC | 1 | 6 | 5.78 | 17 | 9 | 0 | 62.3 | 74 | 12 | 25 | 45 | 1.59 | 16.1 | 9.0 |
| 355 | Francisco Liriano | MIN | 5 | 13 | 5.80 | 29 | 24 | 0 | 136.7 | 147 | 21 | 65 | 122 | 1.55 | 20.0 | 10.7 |
| 356 | Matt Capps | PIT | 4 | 8 | 5.80 | 57 | 0 | 27 | 54.3 | 73 | 10 | 17 | 46 | 1.66 | 18.3 | 6.8 |
| 357 | Yusmeiro Petit | ARI | 3 | 10 | 5.82 | 23 | 17 | 0 | 89.7 | 102 | 19 | 34 | 74 | 1.52 | 18.2 | 8.4 |
| 358 | Virgil Vasquez | PIT | 2 | 5 | 5.84 | 14 | 7 | 0 | 44.7 | 58 | 6 | 18 | 29 | 1.70 | 14.1 | 8.7 |
| 359 | Casey Janssen | TOR | 2 | 4 | 5.85 | 21 | 5 | 1 | 40.0 | 59 | 5 | 14 | 24 | 1.82 | 12.5 | 7.3 |
| 360 | Shane Loux | LAA | 2 | 3 | 5.86 | 18 | 6 | 0 | 58.3 | 84 | 4 | 19 | 19 | 1.77 | 7.0 | 7.0 |
| 361 | Todd Wellemeyer | STL | 7 | 10 | 5.89 | 28 | 21 | 0 | 122.3 | 160 | 19 | 57 | 78 | 1.77 | 13.9 | 10.2 |
| 362 | Glen Perkins | MIN | 6 | 7 | 5.89 | 18 | 17 | 0 | 96.3 | 120 | 13 | 23 | 45 | 1.48 | 10.6 | 5.4 |
| 363 | Matt Lindstrom | FLO | 2 | 1 | 5.89 | 54 | 0 | 15 | 47.3 | 54 | 5 | 24 | 39 | 1.65 | 17.8 | 11.0 |
| 364 | Sean O'Sullivan | LAA | 4 | 2 | 5.92 | 12 | 10 | 0 | 51.7 | 60 | 12 | 16 | 29 | 1.47 | 12.8 | 7.0 |
| 365 | Tomo Ohka | CLE | 1 | 5 | 5.96 | 18 | 6 | 0 | 71.0 | 77 | 18 | 19 | 31 | 1.35 | 10.1 | 6.2 |
| 366 | Santiago Casilla | OAK | 1 | 2 | 5.96 | 46 | 0 | 0 | 48.3 | 61 | 6 | 25 | 35 | 1.78 | 15.0 | 10.7 |
| 367 | Josh Geer | SD | 1 | 7 | 5.96 | 19 | 17 | 0 | 102.7 | 116 | 27 | 23 | 54 | 1.35 | 12.3 | 5.3 |
| 368 | Daniel Cabrera | ARI | 0 | 6 | 6.00 | 15 | 9 | 0 | 51.0 | 59 | 4 | 42 | 23 | 1.98 | 8.9 | 16.3 |
| 369 | Jose Arredondo | LAA | 2 | 3 | 6.00 | 43 | 0 | 0 | 45.0 | 47 | 6 | 23 | 47 | 1.56 | 23.3 | 11.4 |
| 370 | Scott Olsen | WSH | 2 | 4 | 6.03 | 11 | 11 | 0 | 62.7 | 83 | 11 | 25 | 42 | 1.72 | 14.5 | 8.7 |
| 371 | Matt Harrison | TEX | 4 | 5 | 6.11 | 11 | 11 | 0 | 63.3 | 81 | 9 | 23 | 34 | 1.64 | 12.0 | 8.1 |
| 372 | Derek Holland | TEX | 8 | 13 | 6.12 | 33 | 21 | 0 | 138.3 | 160 | 26 | 47 | 107 | 1.50 | 17.5 | 7.7 |
| 373 | David Purcey | TOR | 1 | 3 | 6.19 | 9 | 9 | 0 | 48.0 | 54 | 6 | 30 | 39 | 1.75 | 17.5 | 13.5 |
| 374 | Anthony Swarzak | MIN | 3 | 7 | 6.25 | 12 | 12 | 0 | 59.0 | 76 | 12 | 20 | 34 | 1.63 | 12.7 | 7.5 |
| 375 | Felipe Paulino | HOU | 3 | 11 | 6.27 | 23 | 17 | 0 | 97.7 | 126 | 20 | 37 | 93 | 1.67 | 20.8 | 8.3 |
| 376 | Roberto Hernandez | CLE | 5 | 12 | 6.32 | 24 | 24 | 0 | 125.3 | 151 | 16 | 70 | 79 | 1.76 | 13.3 | 11.7 |
| 377 | John Smoltz | STL | 3 | 8 | 6.35 | 15 | 15 | 0 | 78.0 | 95 | 11 | 18 | 73 | 1.45 | 21.2 | 5.2 |
| 378 | Manny Parra | MIL | 11 | 11 | 6.36 | 27 | 27 | 0 | 140.0 | 179 | 19 | 77 | 116 | 1.83 | 17.3 | 11.5 |
| 379 | Dave Bush | MIL | 5 | 9 | 6.38 | 22 | 21 | 0 | 114.3 | 131 | 19 | 37 | 89 | 1.47 | 17.5 | 7.3 |
| 380 | Billy Buckner | ARI | 4 | 6 | 6.40 | 16 | 13 | 0 | 77.3 | 94 | 12 | 29 | 64 | 1.59 | 18.7 | 8.5 |
| 381 | Jason Berken | BAL | 6 | 12 | 6.54 | 24 | 24 | 0 | 119.7 | 164 | 19 | 44 | 66 | 1.74 | 11.8 | 7.9 |
| 382 | Luke Hochevar | KC | 7 | 13 | 6.55 | 25 | 25 | 0 | 143.0 | 167 | 23 | 46 | 106 | 1.49 | 16.8 | 7.3 |
| 383 | Andy Sonnanstine | TB | 6 | 9 | 6.77 | 22 | 18 | 0 | 99.7 | 131 | 19 | 34 | 60 | 1.66 | 13.1 | 7.4 |
| 384 | Sergio Mitre | NYY | 3 | 3 | 6.79 | 12 | 9 | 0 | 51.7 | 71 | 10 | 13 | 32 | 1.63 | 13.3 | 5.4 |
| 385 | Oliver Perez | NYM | 3 | 4 | 6.82 | 14 | 14 | 0 | 66.0 | 69 | 12 | 58 | 62 | 1.92 | 19.1 | 17.9 |
| 386 | Dana Eveland | OAK | 2 | 4 | 7.16 | 13 | 9 | 0 | 44.0 | 70 | 4 | 26 | 22 | 2.18 | 10.0 | 11.8 |
| 387 | Brad Lidge | PHI | 0 | 8 | 7.21 | 67 | 0 | 31 | 58.7 | 72 | 11 | 34 | 61 | 1.81 | 21.6 | 12.0 |
| 388 | Chris Ray | BAL | 0 | 4 | 7.27 | 46 | 0 | 0 | 43.3 | 64 | 8 | 23 | 39 | 2.01 | 18.2 | 10.7 |
| 389 | Rafael Perez | CLE | 4 | 3 | 7.31 | 54 | 0 | 0 | 48.0 | 66 | 5 | 25 | 32 | 1.90 | 13.9 | 10.9 |
| 390 | Sidney Ponson | KC | 1 | 7 | 7.36 | 14 | 9 | 0 | 58.7 | 79 | 6 | 25 | 32 | 1.77 | 11.7 | 9.2 |
| 391 | Rich Hill | BAL | 3 | 3 | 7.80 | 14 | 13 | 0 | 57.7 | 68 | 7 | 40 | 46 | 1.87 | 16.7 | 14.5 |
| 392 | Adam Eaton | COL | 3 | 5 | 8.08 | 12 | 8 | 0 | 49.0 | 65 | 10 | 27 | 35 | 1.88 | 14.9 | 11.5 |
| 393 | Chien-Ming Wang | NYY | 1 | 6 | 9.64 | 12 | 9 | 0 | 42.0 | 66 | 7 | 19 | 29 | 2.02 | 14.1 | 9.2 |