| # | Player | Team | W | L | ERA | G | GS | SV | IP | H | HR | BB | SO | WHIP | K% | BB% |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Hung-Chih Kuo | LAD | 3 | 2 | 1.20 | 56 | 0 | 12 | 60.0 | 29 | 1 | 18 | 73 | 0.78 | 31.9 | 7.9 |
| 2 | Alexi Ogando | TEX | 4 | 1 | 1.30 | 44 | 0 | 0 | 41.7 | 31 | 2 | 16 | 39 | 1.13 | 22.8 | 9.4 |
| 3 | Joaquin Benoit | TB | 1 | 2 | 1.34 | 63 | 0 | 1 | 60.3 | 30 | 6 | 11 | 75 | 0.68 | 34.6 | 5.1 |
| 4 | Billy Wagner | ATL | 7 | 2 | 1.43 | 71 | 0 | 37 | 69.3 | 38 | 5 | 22 | 104 | 0.87 | 38.8 | 8.2 |
| 5 | Andrew Bailey | OAK | 1 | 3 | 1.47 | 47 | 0 | 25 | 49.0 | 34 | 3 | 13 | 42 | 0.96 | 22.2 | 6.9 |
| 6 | Chris Perez | CLE | 2 | 2 | 1.71 | 63 | 0 | 23 | 63.0 | 40 | 4 | 28 | 61 | 1.08 | 23.5 | 10.8 |
| 7 | Rafael Soriano | TB | 3 | 2 | 1.73 | 64 | 0 | 45 | 62.3 | 36 | 4 | 14 | 57 | 0.80 | 24.1 | 5.9 |
| 8 | Mike Adams | SD | 4 | 1 | 1.75 | 70 | 0 | 0 | 66.7 | 48 | 2 | 23 | 73 | 1.06 | 27.2 | 8.6 |
| 9 | Joakim Soria | KC | 1 | 2 | 1.78 | 66 | 0 | 43 | 65.7 | 53 | 4 | 16 | 71 | 1.05 | 26.3 | 5.9 |
| 10 | Mariano Rivera | NYY | 3 | 3 | 1.80 | 61 | 0 | 33 | 60.0 | 39 | 2 | 11 | 45 | 0.83 | 19.6 | 4.8 |
| 11 | Brian Wilson | SF | 3 | 3 | 1.81 | 70 | 0 | 48 | 74.7 | 62 | 3 | 26 | 93 | 1.18 | 29.9 | 8.4 |
| 12 | Tim Stauffer | SD | 6 | 5 | 1.85 | 32 | 7 | 0 | 82.7 | 65 | 3 | 24 | 61 | 1.08 | 18.7 | 7.4 |
| 13 | Daniel Bard | BOS | 1 | 2 | 1.93 | 73 | 0 | 3 | 74.7 | 45 | 6 | 30 | 76 | 1.00 | 25.8 | 10.2 |
| 14 | Heath Bell | SD | 6 | 1 | 1.93 | 67 | 0 | 47 | 70.0 | 56 | 1 | 28 | 86 | 1.20 | 30.0 | 9.8 |
| 15 | Santiago Casilla | SF | 7 | 2 | 1.95 | 52 | 0 | 2 | 55.3 | 40 | 2 | 26 | 56 | 1.19 | 24.9 | 11.6 |
| 16 | Jonny Venters | ATL | 4 | 4 | 1.95 | 79 | 0 | 1 | 83.0 | 61 | 1 | 39 | 93 | 1.20 | 26.6 | 11.1 |
| 17 | Joel Peralta | WSH | 1 | 0 | 2.02 | 39 | 0 | 0 | 49.0 | 30 | 5 | 9 | 49 | 0.80 | 25.9 | 4.8 |
| 18 | Darren O'Day | TEX | 6 | 2 | 2.03 | 72 | 0 | 0 | 62.0 | 43 | 5 | 12 | 45 | 0.89 | 18.8 | 5.0 |
| 19 | Evan Meek | PIT | 5 | 4 | 2.14 | 70 | 0 | 4 | 80.0 | 53 | 5 | 31 | 70 | 1.05 | 21.6 | 9.6 |
| 20 | Sean Burnett | WSH | 1 | 7 | 2.14 | 73 | 0 | 3 | 63.0 | 52 | 3 | 20 | 62 | 1.14 | 23.8 | 7.7 |
| 21 | Clay Hensley | FLO | 3 | 4 | 2.16 | 68 | 0 | 7 | 75.0 | 54 | 3 | 29 | 77 | 1.11 | 25.1 | 9.4 |
| 22 | Sergio Romo | SF | 5 | 3 | 2.18 | 68 | 0 | 0 | 62.0 | 46 | 6 | 14 | 70 | 0.97 | 28.3 | 5.7 |
| 23 | Francisco Rodriguez | NYM | 4 | 2 | 2.20 | 53 | 0 | 25 | 57.3 | 45 | 3 | 21 | 67 | 1.15 | 28.4 | 8.9 |
| 24 | Jason Motte | STL | 4 | 2 | 2.24 | 56 | 0 | 2 | 52.3 | 41 | 5 | 18 | 54 | 1.13 | 26.0 | 8.7 |
| 25 | Brian Sanches | FLO | 2 | 2 | 2.26 | 61 | 0 | 0 | 63.7 | 43 | 7 | 27 | 54 | 1.10 | 21.3 | 10.6 |
| 26 | Kyle McClellan | STL | 1 | 4 | 2.27 | 68 | 0 | 2 | 75.3 | 58 | 9 | 23 | 60 | 1.08 | 19.5 | 7.5 |
| 27 | Felix Hernandez | SEA | 13 | 12 | 2.27 | 34 | 34 | 0 | 249.7 | 194 | 17 | 70 | 232 | 1.06 | 23.2 | 7.0 |
| 28 | Grant Balfour | TB | 2 | 1 | 2.28 | 57 | 0 | 0 | 55.3 | 43 | 3 | 17 | 56 | 1.08 | 25.2 | 7.7 |
| 29 | Arthur Rhodes | CIN | 4 | 4 | 2.29 | 69 | 0 | 0 | 55.0 | 38 | 4 | 18 | 50 | 1.02 | 23.0 | 8.3 |
| 30 | Elmer Dessens | NYM | 4 | 2 | 2.30 | 53 | 0 | 0 | 47.0 | 41 | 4 | 16 | 16 | 1.21 | 8.2 | 8.2 |
| 31 | Josh Johnson | FLO | 11 | 6 | 2.30 | 28 | 28 | 0 | 183.7 | 155 | 7 | 48 | 186 | 1.11 | 25.0 | 6.5 |
| 32 | Clay Buchholz | BOS | 17 | 7 | 2.33 | 28 | 28 | 0 | 173.7 | 142 | 9 | 67 | 120 | 1.20 | 16.9 | 9.4 |
| 33 | Javier Lopez | SF | 4 | 2 | 2.34 | 77 | 0 | 0 | 57.7 | 50 | 2 | 20 | 38 | 1.21 | 16.2 | 8.5 |
| 34 | Adam Wainwright | STL | 20 | 11 | 2.42 | 33 | 33 | 0 | 230.3 | 186 | 15 | 56 | 213 | 1.05 | 23.4 | 6.2 |
| 35 | Roy Halladay | PHI | 21 | 10 | 2.44 | 33 | 33 | 0 | 250.7 | 231 | 24 | 30 | 219 | 1.04 | 22.1 | 3.0 |
| 36 | Daniel Hudson | ARI | 8 | 2 | 2.45 | 14 | 14 | 0 | 95.3 | 68 | 8 | 27 | 84 | 1.00 | 22.6 | 7.3 |
| 37 | Eric O'Flaherty | ATL | 3 | 2 | 2.45 | 56 | 0 | 0 | 44.0 | 37 | 2 | 18 | 36 | 1.25 | 19.9 | 9.9 |
| 38 | Matt Capps | MIN | 5 | 3 | 2.47 | 74 | 0 | 42 | 73.0 | 75 | 6 | 17 | 59 | 1.26 | 19.3 | 5.6 |
| 39 | Darren Oliver | TEX | 1 | 2 | 2.48 | 64 | 0 | 1 | 61.7 | 53 | 4 | 15 | 65 | 1.10 | 26.6 | 6.1 |
| 40 | John Axford | MIL | 8 | 2 | 2.48 | 50 | 0 | 24 | 58.0 | 42 | 1 | 27 | 76 | 1.19 | 31.9 | 11.3 |
| 41 | Ryan Madson | PHI | 6 | 2 | 2.55 | 55 | 0 | 5 | 53.0 | 42 | 4 | 13 | 64 | 1.04 | 29.5 | 6.0 |
| 42 | Carlos Marmol | CHC | 2 | 3 | 2.55 | 77 | 0 | 38 | 77.7 | 40 | 1 | 52 | 138 | 1.18 | 41.6 | 15.7 |
| 43 | Brian Duensing | MIN | 10 | 3 | 2.62 | 53 | 13 | 0 | 130.7 | 122 | 11 | 35 | 78 | 1.20 | 14.6 | 6.5 |
| 44 | Scott Downs | TOR | 5 | 5 | 2.64 | 67 | 0 | 0 | 61.3 | 47 | 3 | 14 | 48 | 0.99 | 19.9 | 5.8 |
| 45 | Sean Marshall | CHC | 7 | 5 | 2.65 | 80 | 0 | 1 | 74.7 | 58 | 3 | 25 | 90 | 1.11 | 29.3 | 8.1 |
| 46 | Matt Thornton | CWS | 5 | 4 | 2.67 | 61 | 0 | 8 | 60.7 | 41 | 3 | 20 | 81 | 1.01 | 33.9 | 8.4 |
| 47 | Jaime Garcia | STL | 13 | 8 | 2.70 | 28 | 28 | 0 | 163.3 | 151 | 9 | 64 | 132 | 1.32 | 19.0 | 9.2 |
| 48 | David Price | TB | 19 | 6 | 2.72 | 32 | 31 | 0 | 208.7 | 170 | 15 | 79 | 188 | 1.19 | 21.8 | 9.2 |
| 49 | Neftali Feliz | TEX | 4 | 3 | 2.73 | 70 | 0 | 40 | 69.3 | 43 | 5 | 18 | 71 | 0.88 | 26.4 | 6.7 |
| 50 | Roy Oswalt | PHI | 13 | 13 | 2.76 | 33 | 32 | 0 | 211.7 | 162 | 19 | 55 | 193 | 1.03 | 23.1 | 6.6 |
| 51 | Kameron Loe | MIL | 3 | 5 | 2.78 | 53 | 0 | 0 | 58.3 | 54 | 6 | 15 | 46 | 1.18 | 19.2 | 6.2 |
| 52 | Brett Anderson | OAK | 7 | 6 | 2.80 | 19 | 19 | 0 | 112.3 | 112 | 6 | 22 | 75 | 1.19 | 16.0 | 4.7 |
| 53 | Brian Fuentes | MIN | 4 | 1 | 2.81 | 48 | 0 | 24 | 48.0 | 31 | 5 | 20 | 47 | 1.06 | 24.0 | 10.2 |
| 54 | Takashi Saito | ATL | 2 | 3 | 2.83 | 56 | 0 | 1 | 54.0 | 41 | 4 | 17 | 69 | 1.07 | 31.2 | 7.7 |
| 55 | J. J. Putz | CWS | 7 | 5 | 2.83 | 60 | 0 | 3 | 54.0 | 41 | 4 | 15 | 65 | 1.04 | 29.7 | 6.8 |
| 56 | Tim Hudson | ATL | 17 | 9 | 2.83 | 34 | 34 | 0 | 228.7 | 189 | 20 | 74 | 139 | 1.15 | 15.1 | 8.0 |
| 57 | R. A. Dickey | NYM | 11 | 9 | 2.84 | 27 | 26 | 0 | 174.3 | 165 | 13 | 42 | 104 | 1.19 | 14.6 | 5.9 |
| 58 | Koji Uehara | BAL | 1 | 2 | 2.86 | 43 | 0 | 13 | 44.0 | 37 | 5 | 5 | 55 | 0.95 | 31.6 | 2.9 |
| 59 | Ubaldo Jimenez | COL | 19 | 8 | 2.88 | 33 | 33 | 0 | 221.7 | 164 | 10 | 92 | 214 | 1.15 | 23.9 | 10.3 |
| 60 | Ryan Webb | SD | 3 | 1 | 2.90 | 54 | 0 | 0 | 59.0 | 64 | 1 | 19 | 44 | 1.41 | 17.4 | 7.5 |
| 61 | Clayton Kershaw | LAD | 13 | 10 | 2.91 | 32 | 32 | 0 | 204.3 | 160 | 13 | 81 | 212 | 1.18 | 25.0 | 9.6 |
| 62 | Stephen Strasburg | WSH | 5 | 3 | 2.91 | 12 | 12 | 0 | 68.0 | 56 | 5 | 17 | 92 | 1.07 | 33.6 | 6.2 |
| 63 | Mat Latos | SD | 14 | 10 | 2.92 | 31 | 31 | 0 | 184.7 | 150 | 16 | 50 | 189 | 1.08 | 25.3 | 6.7 |
| 64 | Boone Logan | NYY | 2 | 0 | 2.92 | 51 | 0 | 0 | 40.0 | 34 | 3 | 20 | 38 | 1.35 | 22.5 | 11.8 |
| 65 | Matt Belisle | COL | 7 | 5 | 2.93 | 76 | 0 | 1 | 92.0 | 84 | 7 | 16 | 91 | 1.09 | 24.9 | 4.4 |
| 66 | Wilton Lopez | HOU | 5 | 2 | 2.96 | 68 | 0 | 1 | 67.0 | 66 | 4 | 5 | 50 | 1.06 | 19.1 | 1.9 |
| 67 | Brad Lidge | PHI | 1 | 1 | 2.96 | 50 | 0 | 27 | 45.7 | 32 | 5 | 24 | 52 | 1.23 | 26.9 | 12.4 |
| 68 | Sergio Santos | CWS | 2 | 2 | 2.96 | 56 | 0 | 1 | 51.7 | 53 | 2 | 26 | 56 | 1.53 | 23.8 | 11.1 |
| 69 | Peter Moylan | ATL | 6 | 2 | 2.97 | 85 | 0 | 1 | 63.7 | 53 | 5 | 37 | 52 | 1.41 | 19.2 | 13.7 |
| 70 | Trevor Cahill | OAK | 18 | 8 | 2.97 | 30 | 30 | 0 | 196.7 | 155 | 19 | 63 | 118 | 1.11 | 15.1 | 8.0 |
| 71 | Johan Santana | NYM | 11 | 9 | 2.98 | 29 | 29 | 0 | 199.0 | 179 | 16 | 55 | 144 | 1.18 | 17.6 | 6.7 |
| 72 | Ramon Ramirez | SF | 1 | 3 | 2.99 | 69 | 0 | 3 | 69.3 | 52 | 7 | 27 | 46 | 1.14 | 16.2 | 9.5 |
| 73 | Shawn Camp | TOR | 4 | 3 | 2.99 | 70 | 0 | 2 | 72.3 | 71 | 8 | 18 | 46 | 1.23 | 15.4 | 6.0 |
| 74 | Jose Valverde | DET | 2 | 4 | 3.00 | 60 | 0 | 26 | 63.0 | 41 | 5 | 32 | 63 | 1.16 | 24.3 | 12.4 |
| 75 | Madison Bumgarner | SF | 7 | 6 | 3.00 | 18 | 18 | 0 | 111.0 | 119 | 11 | 26 | 86 | 1.31 | 18.2 | 5.5 |
| 76 | Jered Weaver | LAA | 13 | 12 | 3.01 | 34 | 34 | 0 | 224.3 | 187 | 23 | 54 | 233 | 1.07 | 25.7 | 6.0 |
| 77 | Craig Breslow | OAK | 4 | 4 | 3.01 | 75 | 0 | 5 | 74.7 | 53 | 9 | 29 | 71 | 1.10 | 23.4 | 9.5 |
| 78 | Jason Berken | BAL | 3 | 3 | 3.03 | 41 | 0 | 0 | 62.3 | 64 | 5 | 19 | 45 | 1.33 | 17.2 | 7.3 |
| 79 | Jesse Crain | MIN | 1 | 1 | 3.04 | 71 | 0 | 1 | 68.0 | 53 | 5 | 27 | 62 | 1.18 | 22.3 | 9.7 |
| 80 | Cole Hamels | PHI | 12 | 11 | 3.06 | 33 | 33 | 0 | 208.7 | 185 | 26 | 61 | 211 | 1.18 | 24.6 | 7.1 |
| 81 | Tyler Clippard | WSH | 11 | 8 | 3.07 | 78 | 0 | 1 | 91.0 | 69 | 8 | 41 | 112 | 1.21 | 29.6 | 10.8 |
| 82 | Jonathan Sanchez | SF | 13 | 9 | 3.07 | 34 | 33 | 0 | 193.3 | 142 | 21 | 96 | 205 | 1.23 | 25.2 | 11.8 |
| 83 | Doug Slaten | WSH | 4 | 1 | 3.10 | 49 | 0 | 0 | 40.7 | 34 | 2 | 19 | 36 | 1.30 | 20.7 | 10.9 |
| 84 | Brandon Lyon | HOU | 6 | 6 | 3.12 | 79 | 0 | 20 | 78.0 | 68 | 2 | 31 | 54 | 1.27 | 16.2 | 9.3 |
| 85 | Jon Rauch | MIN | 3 | 1 | 3.12 | 59 | 0 | 21 | 57.7 | 61 | 3 | 14 | 46 | 1.30 | 18.8 | 5.7 |
| 86 | Kerry Wood | NYY | 3 | 4 | 3.13 | 47 | 0 | 8 | 46.0 | 35 | 4 | 29 | 49 | 1.39 | 24.4 | 14.4 |
| 87 | Brett Myers | HOU | 14 | 8 | 3.14 | 33 | 33 | 0 | 223.7 | 212 | 20 | 66 | 180 | 1.24 | 19.2 | 7.1 |
| 88 | Matt Cain | SF | 13 | 11 | 3.14 | 33 | 33 | 0 | 223.3 | 181 | 22 | 61 | 177 | 1.08 | 19.8 | 6.8 |
| 89 | Matt Guerrier | MIN | 5 | 7 | 3.17 | 74 | 0 | 1 | 71.0 | 56 | 7 | 22 | 42 | 1.10 | 14.7 | 7.7 |
| 90 | Cliff Lee | TEX | 12 | 9 | 3.18 | 28 | 28 | 0 | 212.3 | 195 | 16 | 18 | 185 | 1.00 | 21.9 | 2.1 |
| 91 | CC Sabathia | NYY | 21 | 7 | 3.18 | 34 | 34 | 0 | 237.7 | 209 | 20 | 74 | 197 | 1.19 | 20.3 | 7.6 |
| 92 | Will Ohman | FLO | 0 | 2 | 3.21 | 68 | 0 | 0 | 42.0 | 40 | 4 | 23 | 43 | 1.50 | 23.1 | 12.4 |
| 93 | Chris Carpenter | STL | 16 | 9 | 3.22 | 35 | 35 | 0 | 235.0 | 214 | 21 | 63 | 179 | 1.18 | 18.5 | 6.5 |
| 94 | Luke Gregerson | SD | 4 | 7 | 3.22 | 80 | 0 | 2 | 78.3 | 47 | 8 | 18 | 89 | 0.83 | 30.0 | 6.1 |
| 95 | Gio Gonzalez | OAK | 15 | 9 | 3.23 | 33 | 33 | 0 | 200.7 | 171 | 15 | 92 | 171 | 1.31 | 20.1 | 10.8 |
| 96 | Brad Penny | STL | 3 | 4 | 3.23 | 9 | 9 | 0 | 55.7 | 63 | 4 | 9 | 35 | 1.29 | 15.1 | 3.9 |
| 97 | Jon Lester | BOS | 19 | 9 | 3.25 | 32 | 32 | 0 | 208.0 | 167 | 14 | 83 | 225 | 1.20 | 26.1 | 9.6 |
| 98 | Rafael Perez | CLE | 6 | 1 | 3.25 | 70 | 0 | 0 | 61.0 | 72 | 3 | 25 | 36 | 1.59 | 13.2 | 9.2 |
| 99 | Brad Ziegler | OAK | 3 | 7 | 3.26 | 64 | 0 | 0 | 60.7 | 54 | 4 | 28 | 41 | 1.35 | 16.0 | 10.9 |
| 100 | Jhoulys Chacin | COL | 9 | 11 | 3.28 | 28 | 21 | 0 | 137.3 | 114 | 10 | 61 | 138 | 1.27 | 23.7 | 10.5 |
| 101 | Andy Pettitte | NYY | 11 | 3 | 3.28 | 21 | 21 | 0 | 129.0 | 123 | 13 | 41 | 101 | 1.27 | 18.8 | 7.6 |
| 102 | Nelson Figueroa | HOU | 7 | 4 | 3.29 | 31 | 11 | 1 | 93.0 | 84 | 10 | 34 | 73 | 1.27 | 18.7 | 8.7 |
| 103 | Pedro Feliciano | NYM | 3 | 6 | 3.30 | 92 | 0 | 0 | 62.7 | 66 | 1 | 30 | 56 | 1.53 | 20.0 | 10.7 |
| 104 | Tommy Hanson | ATL | 10 | 11 | 3.33 | 34 | 34 | 0 | 202.7 | 182 | 14 | 56 | 173 | 1.17 | 20.5 | 6.6 |
| 105 | Carlos Zambrano | CHC | 11 | 6 | 3.33 | 36 | 20 | 0 | 129.7 | 119 | 7 | 69 | 117 | 1.45 | 20.5 | 12.1 |
| 106 | Sergio Mitre | NYY | 0 | 3 | 3.33 | 27 | 3 | 1 | 54.0 | 43 | 7 | 16 | 29 | 1.09 | 13.6 | 7.5 |
| 107 | Jose Contreras | PHI | 6 | 4 | 3.34 | 67 | 0 | 4 | 56.7 | 53 | 5 | 16 | 57 | 1.22 | 24.5 | 6.9 |
| 108 | Kyle Farnsworth | ATL | 3 | 2 | 3.34 | 60 | 0 | 0 | 64.7 | 55 | 4 | 19 | 61 | 1.14 | 22.8 | 7.1 |
| 109 | Dan Wheeler | TB | 2 | 4 | 3.35 | 64 | 0 | 3 | 48.3 | 36 | 7 | 16 | 46 | 1.08 | 23.6 | 8.2 |
| 110 | C. J. Wilson | TEX | 15 | 8 | 3.35 | 33 | 33 | 0 | 204.0 | 161 | 10 | 93 | 170 | 1.25 | 20.0 | 10.9 |
| 111 | Justin Verlander | DET | 18 | 9 | 3.37 | 33 | 33 | 0 | 224.3 | 190 | 14 | 71 | 219 | 1.16 | 23.7 | 7.7 |
| 112 | Hiroki Kuroda | LAD | 11 | 13 | 3.39 | 31 | 31 | 0 | 196.3 | 180 | 15 | 48 | 159 | 1.16 | 19.6 | 5.9 |
| 113 | Joe Beimel | COL | 1 | 2 | 3.40 | 71 | 0 | 0 | 45.0 | 46 | 5 | 15 | 21 | 1.36 | 11.2 | 8.0 |
| 114 | J. A. Happ | HOU | 6 | 4 | 3.40 | 16 | 16 | 0 | 87.3 | 73 | 8 | 47 | 70 | 1.37 | 18.7 | 12.6 |
| 115 | Nick Masset | CIN | 4 | 4 | 3.40 | 82 | 0 | 2 | 76.7 | 64 | 7 | 33 | 85 | 1.27 | 26.4 | 10.2 |
| 116 | Brandon League | SEA | 9 | 7 | 3.42 | 70 | 0 | 6 | 79.0 | 67 | 7 | 27 | 56 | 1.19 | 17.2 | 8.3 |
| 117 | Tim Lincecum | SF | 16 | 10 | 3.43 | 33 | 33 | 0 | 212.3 | 194 | 18 | 76 | 231 | 1.27 | 25.8 | 8.5 |
| 118 | David Aardsma | SEA | 0 | 6 | 3.44 | 53 | 0 | 31 | 49.7 | 33 | 5 | 25 | 49 | 1.17 | 24.3 | 12.4 |
| 119 | Juan Carlos Oviedo | FLO | 4 | 3 | 3.46 | 68 | 0 | 30 | 65.0 | 62 | 5 | 21 | 71 | 1.28 | 26.3 | 7.8 |
| 120 | Ryan Franklin | STL | 6 | 2 | 3.46 | 59 | 0 | 27 | 65.0 | 57 | 7 | 10 | 42 | 1.03 | 15.9 | 3.8 |
| 121 | Jon Garland | SD | 14 | 12 | 3.46 | 33 | 33 | 0 | 200.0 | 176 | 20 | 87 | 136 | 1.31 | 16.2 | 10.4 |
| 122 | Max Scherzer | DET | 12 | 11 | 3.50 | 31 | 31 | 0 | 195.7 | 174 | 20 | 70 | 184 | 1.25 | 23.0 | 8.8 |
| 123 | Dallas Braden | OAK | 11 | 14 | 3.50 | 30 | 30 | 0 | 192.7 | 180 | 17 | 43 | 113 | 1.16 | 14.5 | 5.5 |
| 124 | Travis Wood | CIN | 5 | 4 | 3.51 | 17 | 17 | 0 | 102.7 | 85 | 9 | 26 | 86 | 1.08 | 20.5 | 6.2 |
| 125 | Kevin Gregg | TOR | 2 | 6 | 3.51 | 63 | 0 | 37 | 59.0 | 52 | 4 | 30 | 58 | 1.39 | 22.8 | 11.8 |
| 126 | Rob Tejeda | KC | 3 | 5 | 3.54 | 54 | 0 | 0 | 61.0 | 55 | 5 | 26 | 56 | 1.33 | 21.7 | 10.1 |
| 127 | Anibal Sanchez | FLO | 13 | 12 | 3.55 | 32 | 32 | 0 | 195.0 | 192 | 10 | 70 | 157 | 1.34 | 18.7 | 8.3 |
| 128 | Chad Billingsley | LAD | 12 | 11 | 3.57 | 31 | 31 | 0 | 191.7 | 176 | 8 | 69 | 171 | 1.28 | 20.9 | 8.4 |
| 129 | Drew Storen | WSH | 4 | 4 | 3.58 | 54 | 0 | 5 | 55.3 | 48 | 3 | 22 | 52 | 1.27 | 22.4 | 9.5 |
| 130 | Ryan Perry | DET | 3 | 5 | 3.59 | 60 | 0 | 2 | 62.7 | 55 | 6 | 23 | 45 | 1.24 | 17.2 | 8.8 |
| 131 | Wandy Rodriguez | HOU | 11 | 12 | 3.60 | 32 | 32 | 0 | 195.0 | 183 | 16 | 68 | 178 | 1.29 | 21.7 | 8.3 |
| 132 | Mitchell Boggs | STL | 2 | 3 | 3.61 | 61 | 0 | 0 | 67.3 | 60 | 5 | 27 | 52 | 1.29 | 18.2 | 9.5 |
| 133 | Rafael Betancourt | COL | 5 | 1 | 3.61 | 72 | 0 | 1 | 62.3 | 52 | 9 | 8 | 89 | 0.96 | 35.9 | 3.2 |
| 134 | Huston Street | COL | 4 | 4 | 3.61 | 44 | 0 | 20 | 47.3 | 39 | 5 | 11 | 45 | 1.06 | 24.1 | 5.9 |
| 135 | Hisanori Takahashi | NYM | 10 | 6 | 3.61 | 53 | 12 | 8 | 122.0 | 116 | 13 | 43 | 114 | 1.30 | 22.1 | 8.3 |
| 136 | Francisco Liriano | MIN | 14 | 10 | 3.62 | 31 | 31 | 0 | 191.7 | 184 | 9 | 58 | 201 | 1.26 | 24.9 | 7.2 |
| 137 | Joel Hanrahan | PIT | 4 | 1 | 3.62 | 72 | 0 | 6 | 69.7 | 58 | 6 | 26 | 100 | 1.21 | 34.0 | 8.8 |
| 138 | Edward Mujica | SD | 2 | 1 | 3.62 | 59 | 0 | 0 | 69.7 | 59 | 14 | 6 | 72 | 0.93 | 26.9 | 2.2 |
| 139 | Ted Lilly | LAD | 10 | 12 | 3.62 | 30 | 30 | 0 | 193.7 | 165 | 32 | 44 | 166 | 1.08 | 21.1 | 5.6 |
| 140 | Johnny Cueto | CIN | 12 | 7 | 3.64 | 31 | 31 | 0 | 185.7 | 181 | 19 | 56 | 138 | 1.28 | 17.7 | 7.2 |
| 141 | Shaun Marcum | TOR | 13 | 8 | 3.64 | 31 | 31 | 0 | 195.3 | 181 | 24 | 43 | 165 | 1.15 | 20.6 | 5.4 |
| 142 | Livan Hernandez | WSH | 10 | 12 | 3.66 | 33 | 33 | 0 | 211.7 | 216 | 16 | 64 | 114 | 1.32 | 12.7 | 7.1 |
| 143 | Mike Pelfrey | NYM | 15 | 9 | 3.66 | 34 | 33 | 1 | 204.0 | 213 | 12 | 68 | 113 | 1.38 | 13.0 | 7.8 |
| 144 | Casey Janssen | TOR | 5 | 2 | 3.67 | 56 | 0 | 0 | 68.7 | 74 | 8 | 21 | 63 | 1.38 | 21.1 | 7.0 |
| 145 | Jason Frasor | TOR | 3 | 4 | 3.68 | 69 | 0 | 4 | 63.7 | 61 | 4 | 27 | 65 | 1.38 | 23.3 | 9.7 |
| 146 | D. J. Carrasco | ARI | 3 | 2 | 3.68 | 63 | 0 | 0 | 78.3 | 68 | 5 | 34 | 65 | 1.30 | 19.7 | 10.3 |
| 147 | Kris Medlen | ATL | 6 | 2 | 3.68 | 31 | 14 | 0 | 107.7 | 108 | 13 | 21 | 83 | 1.20 | 18.9 | 4.8 |
| 148 | Logan Ondrusek | CIN | 5 | 0 | 3.68 | 60 | 0 | 0 | 58.7 | 49 | 7 | 20 | 39 | 1.18 | 16.2 | 8.3 |
| 149 | Jerry Blevins | OAK | 2 | 1 | 3.70 | 63 | 0 | 1 | 48.7 | 54 | 7 | 18 | 46 | 1.48 | 20.9 | 8.2 |
| 150 | Miguel Batista | WSH | 1 | 2 | 3.70 | 58 | 1 | 2 | 82.7 | 71 | 9 | 39 | 55 | 1.33 | 15.7 | 11.1 |
| 151 | Colby Lewis | TEX | 12 | 13 | 3.72 | 32 | 32 | 0 | 201.0 | 174 | 21 | 65 | 196 | 1.19 | 23.2 | 7.7 |
| 152 | John Danks | CWS | 15 | 11 | 3.72 | 32 | 32 | 0 | 213.0 | 189 | 18 | 70 | 162 | 1.22 | 18.5 | 8.0 |
| 153 | Chris Ray | SF | 5 | 0 | 3.72 | 63 | 0 | 2 | 55.7 | 48 | 5 | 25 | 31 | 1.31 | 13.2 | 10.7 |
| 154 | Tommy Hunter | TEX | 13 | 4 | 3.73 | 23 | 22 | 0 | 128.0 | 126 | 21 | 33 | 68 | 1.24 | 12.7 | 6.2 |
| 155 | Ricky Romero | TOR | 14 | 9 | 3.73 | 32 | 32 | 0 | 210.0 | 189 | 15 | 82 | 174 | 1.29 | 19.7 | 9.3 |
| 156 | Alex Sanabia | FLO | 5 | 3 | 3.73 | 15 | 12 | 0 | 72.3 | 74 | 6 | 16 | 47 | 1.24 | 15.3 | 5.2 |
| 157 | Carl Pavano | MIN | 17 | 11 | 3.75 | 32 | 32 | 0 | 221.0 | 227 | 24 | 37 | 117 | 1.19 | 12.9 | 4.1 |
| 158 | Clayton Richard | SD | 14 | 9 | 3.75 | 33 | 33 | 0 | 201.7 | 206 | 16 | 78 | 153 | 1.41 | 17.8 | 9.1 |
| 159 | Jose Veras | FLO | 3 | 3 | 3.75 | 48 | 0 | 0 | 48.0 | 32 | 5 | 29 | 54 | 1.27 | 26.9 | 14.4 |
| 160 | Phil Coke | DET | 7 | 5 | 3.76 | 74 | 1 | 2 | 64.7 | 67 | 2 | 26 | 53 | 1.44 | 19.0 | 9.3 |
| 161 | Frank Francisco | TEX | 6 | 4 | 3.76 | 56 | 0 | 2 | 52.7 | 49 | 5 | 18 | 60 | 1.27 | 27.1 | 8.1 |
| 162 | Roberto Hernandez | CLE | 13 | 14 | 3.77 | 33 | 33 | 0 | 210.3 | 203 | 17 | 72 | 124 | 1.31 | 14.1 | 8.2 |
| 163 | Jason Vargas | SEA | 9 | 12 | 3.78 | 31 | 31 | 0 | 192.7 | 187 | 18 | 54 | 116 | 1.25 | 14.3 | 6.7 |
| 164 | Chad Durbin | PHI | 4 | 1 | 3.80 | 64 | 0 | 0 | 68.7 | 63 | 7 | 27 | 63 | 1.31 | 21.6 | 9.3 |
| 165 | Ian Kennedy | ARI | 9 | 10 | 3.80 | 32 | 32 | 0 | 194.0 | 163 | 26 | 70 | 168 | 1.20 | 20.7 | 8.6 |
| 166 | David Robertson | NYY | 4 | 5 | 3.82 | 64 | 0 | 1 | 61.3 | 59 | 5 | 33 | 71 | 1.50 | 26.0 | 12.1 |
| 167 | Joe Smith | CLE | 2 | 2 | 3.83 | 53 | 0 | 0 | 40.0 | 30 | 4 | 24 | 32 | 1.35 | 18.8 | 14.1 |
| 168 | Jeremy Guthrie | BAL | 11 | 14 | 3.83 | 32 | 32 | 0 | 209.3 | 193 | 25 | 50 | 119 | 1.16 | 13.6 | 5.7 |
| 169 | Carlos Carrasco | CLE | 2 | 2 | 3.83 | 7 | 7 | 0 | 44.7 | 47 | 6 | 14 | 38 | 1.37 | 20.2 | 7.4 |
| 170 | Dusty Hughes | KC | 1 | 3 | 3.83 | 57 | 0 | 0 | 56.3 | 59 | 3 | 24 | 34 | 1.47 | 13.5 | 9.5 |
| 171 | Francisco Cordero | CIN | 6 | 5 | 3.84 | 75 | 0 | 40 | 72.7 | 68 | 5 | 36 | 59 | 1.43 | 18.7 | 11.4 |
| 172 | Joel Pineiro | LAA | 10 | 7 | 3.84 | 23 | 23 | 0 | 152.3 | 155 | 15 | 34 | 92 | 1.24 | 14.5 | 5.4 |
| 173 | Yovani Gallardo | MIL | 14 | 7 | 3.84 | 31 | 31 | 0 | 185.0 | 178 | 12 | 75 | 200 | 1.37 | 24.9 | 9.3 |
| 174 | Ryan Dempster | CHC | 15 | 12 | 3.85 | 34 | 34 | 0 | 215.3 | 198 | 25 | 86 | 208 | 1.32 | 22.7 | 9.4 |
| 175 | Jordan Smith | CIN | 3 | 2 | 3.86 | 37 | 0 | 1 | 42.0 | 45 | 7 | 11 | 26 | 1.33 | 14.5 | 6.1 |
| 176 | Bronson Arroyo | CIN | 17 | 10 | 3.88 | 33 | 33 | 0 | 215.7 | 188 | 29 | 59 | 121 | 1.15 | 13.8 | 6.7 |
| 177 | Brad Thomas | DET | 6 | 2 | 3.89 | 49 | 2 | 0 | 69.3 | 77 | 4 | 29 | 30 | 1.53 | 9.8 | 9.4 |
| 178 | Jonathan Papelbon | BOS | 5 | 7 | 3.90 | 65 | 0 | 37 | 67.0 | 57 | 7 | 28 | 76 | 1.27 | 26.5 | 9.8 |
| 179 | Dan Haren | LAA | 12 | 12 | 3.91 | 35 | 35 | 0 | 235.0 | 245 | 31 | 54 | 216 | 1.27 | 21.7 | 5.4 |
| 180 | Barry Enright | ARI | 6 | 7 | 3.91 | 17 | 17 | 0 | 99.0 | 97 | 20 | 29 | 49 | 1.27 | 12.0 | 7.1 |
| 181 | Matt Garza | TB | 15 | 10 | 3.91 | 33 | 32 | 1 | 204.7 | 193 | 28 | 63 | 150 | 1.25 | 17.5 | 7.4 |
| 182 | Lance Cormier | TB | 4 | 3 | 3.92 | 60 | 0 | 0 | 62.0 | 68 | 7 | 34 | 30 | 1.65 | 10.8 | 12.2 |
| 183 | Ervin Santana | LAA | 17 | 10 | 3.92 | 33 | 33 | 0 | 222.7 | 221 | 27 | 73 | 169 | 1.32 | 17.7 | 7.7 |
| 184 | Chris Capuano | MIL | 4 | 4 | 3.95 | 24 | 9 | 0 | 66.0 | 65 | 9 | 21 | 54 | 1.30 | 19.4 | 7.6 |
| 185 | Kevin Jepsen | LAA | 2 | 4 | 3.97 | 68 | 0 | 0 | 59.0 | 54 | 2 | 29 | 61 | 1.41 | 24.1 | 11.5 |
| 186 | Burke Badenhop | FLO | 2 | 5 | 3.99 | 53 | 0 | 1 | 67.7 | 62 | 5 | 21 | 47 | 1.23 | 16.7 | 7.5 |
| 187 | Derek Lowe | ATL | 16 | 12 | 4.00 | 33 | 33 | 0 | 193.7 | 204 | 18 | 61 | 136 | 1.37 | 16.5 | 7.4 |
| 188 | James McDonald | PIT | 4 | 6 | 4.02 | 15 | 12 | 0 | 71.7 | 70 | 4 | 29 | 68 | 1.38 | 22.2 | 9.5 |
| 189 | Frank Herrmann | CLE | 0 | 1 | 4.03 | 40 | 0 | 1 | 44.7 | 48 | 6 | 9 | 24 | 1.28 | 12.7 | 4.8 |
| 190 | Jonathan Broxton | LAD | 5 | 6 | 4.04 | 64 | 0 | 22 | 62.3 | 64 | 4 | 28 | 73 | 1.48 | 26.9 | 10.3 |
| 191 | David Pauley | SEA | 4 | 9 | 4.07 | 19 | 15 | 0 | 90.7 | 89 | 13 | 30 | 51 | 1.31 | 13.1 | 7.7 |
| 192 | Ross Ohlendorf | PIT | 1 | 11 | 4.07 | 21 | 21 | 0 | 108.3 | 106 | 12 | 44 | 79 | 1.38 | 16.6 | 9.3 |
| 193 | Wade Davis | TB | 12 | 10 | 4.07 | 29 | 29 | 0 | 168.0 | 165 | 24 | 62 | 113 | 1.35 | 15.7 | 8.6 |
| 194 | Vicente Padilla | LAD | 6 | 5 | 4.07 | 16 | 16 | 0 | 95.0 | 79 | 14 | 24 | 84 | 1.08 | 21.6 | 6.2 |
| 195 | Octavio Dotel | COL | 3 | 4 | 4.08 | 68 | 0 | 22 | 64.0 | 52 | 9 | 32 | 75 | 1.31 | 26.9 | 11.5 |
| 196 | Derek Holland | TEX | 3 | 4 | 4.08 | 14 | 10 | 0 | 57.3 | 55 | 6 | 24 | 54 | 1.38 | 21.3 | 9.5 |
| 197 | Gavin Floyd | CWS | 10 | 13 | 4.08 | 31 | 31 | 0 | 187.3 | 199 | 14 | 58 | 151 | 1.37 | 18.9 | 7.3 |
| 198 | Tom Gorzelanny | CHC | 7 | 9 | 4.09 | 29 | 23 | 1 | 136.3 | 136 | 11 | 68 | 119 | 1.50 | 19.7 | 11.3 |
| 199 | Casey Coleman | CHC | 4 | 2 | 4.11 | 12 | 8 | 0 | 57.0 | 56 | 3 | 25 | 27 | 1.42 | 10.9 | 10.1 |
| 200 | Doug Fister | SEA | 6 | 14 | 4.11 | 28 | 28 | 0 | 171.0 | 187 | 13 | 32 | 93 | 1.28 | 12.9 | 4.4 |
| 201 | J. D. Martin | WSH | 1 | 5 | 4.12 | 9 | 9 | 0 | 48.0 | 56 | 9 | 11 | 31 | 1.40 | 14.6 | 5.2 |
| 202 | Jeremy Affeldt | SF | 4 | 3 | 4.14 | 53 | 0 | 4 | 50.0 | 56 | 4 | 24 | 44 | 1.60 | 19.3 | 10.5 |
| 203 | Tony Sipp | CLE | 2 | 2 | 4.14 | 70 | 0 | 1 | 63.0 | 48 | 12 | 39 | 69 | 1.38 | 25.9 | 14.7 |
| 204 | Barry Zito | SF | 9 | 14 | 4.15 | 34 | 33 | 0 | 199.3 | 184 | 20 | 84 | 150 | 1.34 | 17.7 | 9.9 |
| 205 | Jamey Wright | SEA | 1 | 3 | 4.17 | 46 | 0 | 0 | 58.3 | 55 | 3 | 25 | 28 | 1.37 | 11.2 | 10.0 |
| 206 | Bruce Chen | KC | 12 | 7 | 4.17 | 33 | 23 | 1 | 140.3 | 136 | 17 | 57 | 98 | 1.38 | 16.1 | 9.4 |
| 207 | Zack Greinke | KC | 10 | 14 | 4.17 | 33 | 33 | 0 | 220.0 | 219 | 18 | 55 | 181 | 1.25 | 19.7 | 6.0 |
| 208 | Randy Wolf | MIL | 13 | 12 | 4.17 | 34 | 34 | 0 | 215.7 | 213 | 29 | 87 | 142 | 1.39 | 15.2 | 9.3 |
| 209 | Phil Hughes | NYY | 18 | 8 | 4.19 | 31 | 29 | 0 | 176.3 | 162 | 25 | 58 | 146 | 1.25 | 20.0 | 7.9 |
| 210 | Jonathon Niese | NYM | 9 | 10 | 4.20 | 30 | 30 | 0 | 173.7 | 192 | 20 | 62 | 148 | 1.46 | 19.2 | 8.1 |
| 211 | Jorge De La Rosa | COL | 8 | 7 | 4.22 | 20 | 20 | 0 | 121.7 | 105 | 15 | 55 | 113 | 1.32 | 22.1 | 10.7 |
| 212 | Jake Westbrook | STL | 10 | 11 | 4.22 | 33 | 33 | 0 | 202.7 | 203 | 20 | 68 | 128 | 1.34 | 14.9 | 7.9 |
| 213 | Carlos Silva | CHC | 10 | 6 | 4.22 | 21 | 21 | 0 | 113.0 | 120 | 11 | 24 | 80 | 1.27 | 16.7 | 5.0 |
| 214 | Brett Cecil | TOR | 15 | 7 | 4.22 | 28 | 28 | 0 | 172.7 | 175 | 18 | 54 | 117 | 1.33 | 16.1 | 7.4 |
| 215 | Mike Leake | CIN | 8 | 4 | 4.23 | 24 | 22 | 0 | 138.3 | 158 | 19 | 49 | 91 | 1.50 | 15.1 | 8.1 |
| 216 | Randy Choate | TB | 4 | 3 | 4.23 | 85 | 0 | 0 | 44.7 | 41 | 3 | 17 | 40 | 1.30 | 21.4 | 9.1 |
| 217 | Fernando Rodney | LAA | 4 | 3 | 4.24 | 72 | 0 | 14 | 68.0 | 70 | 4 | 35 | 53 | 1.54 | 17.2 | 11.4 |
| 218 | Wade LeBlanc | SD | 8 | 12 | 4.25 | 26 | 25 | 0 | 146.0 | 157 | 24 | 51 | 110 | 1.42 | 17.6 | 8.2 |
| 219 | Randy Wells | CHC | 8 | 14 | 4.26 | 32 | 32 | 0 | 194.3 | 209 | 19 | 63 | 144 | 1.40 | 17.1 | 7.5 |
| 220 | Blaine Boyer | ARI | 3 | 2 | 4.26 | 54 | 0 | 0 | 57.0 | 59 | 3 | 29 | 29 | 1.54 | 11.6 | 11.6 |
| 221 | Vin Mazzaro | OAK | 6 | 8 | 4.27 | 24 | 18 | 0 | 122.3 | 127 | 19 | 50 | 79 | 1.45 | 14.7 | 9.3 |
| 222 | Mark Buehrle | CWS | 13 | 13 | 4.28 | 33 | 33 | 0 | 210.3 | 246 | 17 | 49 | 99 | 1.40 | 11.0 | 5.5 |
| 223 | Dustin Nippert | TEX | 4 | 5 | 4.29 | 38 | 2 | 0 | 56.7 | 61 | 7 | 34 | 47 | 1.68 | 17.9 | 13.0 |
| 224 | David Herndon | PHI | 1 | 3 | 4.30 | 47 | 0 | 0 | 52.3 | 67 | 2 | 17 | 29 | 1.61 | 12.5 | 7.3 |
| 225 | Brian Matusz | BAL | 10 | 12 | 4.30 | 32 | 32 | 0 | 175.7 | 173 | 19 | 63 | 143 | 1.34 | 18.8 | 8.3 |
| 226 | Edinson Volquez | CIN | 4 | 3 | 4.31 | 12 | 12 | 0 | 62.7 | 59 | 6 | 35 | 67 | 1.50 | 24.4 | 12.7 |
| 227 | David Hernandez | BAL | 8 | 8 | 4.31 | 41 | 8 | 2 | 79.3 | 72 | 9 | 42 | 72 | 1.44 | 20.7 | 12.1 |
| 228 | Ramon Troncoso | LAD | 2 | 3 | 4.33 | 52 | 0 | 0 | 54.0 | 55 | 7 | 18 | 34 | 1.35 | 14.5 | 7.7 |
| 229 | Guillermo Mota | SF | 1 | 3 | 4.33 | 56 | 0 | 1 | 54.0 | 49 | 4 | 22 | 38 | 1.31 | 16.7 | 9.6 |
| 230 | Francisco Rodriguez | LAA | 1 | 3 | 4.37 | 43 | 0 | 0 | 47.3 | 46 | 5 | 26 | 36 | 1.52 | 17.2 | 12.4 |
| 231 | Carlos Monasterios | LAD | 3 | 5 | 4.38 | 32 | 13 | 0 | 88.3 | 99 | 15 | 29 | 52 | 1.45 | 13.0 | 7.3 |
| 232 | Matt Lindstrom | HOU | 2 | 5 | 4.39 | 58 | 0 | 23 | 53.3 | 68 | 5 | 20 | 43 | 1.65 | 17.6 | 8.2 |
| 233 | Jeff Niemann | TB | 12 | 8 | 4.39 | 30 | 29 | 0 | 174.3 | 159 | 25 | 61 | 131 | 1.26 | 17.9 | 8.3 |
| 234 | Joba Chamberlain | NYY | 3 | 4 | 4.40 | 73 | 0 | 3 | 71.7 | 71 | 6 | 22 | 77 | 1.30 | 25.2 | 7.2 |
| 235 | Scott Linebrink | CWS | 3 | 2 | 4.40 | 52 | 0 | 0 | 57.3 | 59 | 11 | 17 | 52 | 1.33 | 20.9 | 6.8 |
| 236 | John Lackey | BOS | 14 | 11 | 4.40 | 33 | 33 | 0 | 215.0 | 233 | 18 | 72 | 156 | 1.42 | 16.8 | 7.7 |
| 237 | Mitch Talbot | CLE | 10 | 13 | 4.41 | 28 | 28 | 0 | 159.3 | 169 | 13 | 69 | 88 | 1.49 | 12.6 | 9.9 |
| 238 | Bobby Jenks | CWS | 1 | 3 | 4.44 | 55 | 0 | 27 | 52.7 | 54 | 3 | 18 | 61 | 1.37 | 26.4 | 7.8 |
| 239 | Andy Sonnanstine | TB | 3 | 1 | 4.44 | 41 | 4 | 1 | 81.0 | 83 | 11 | 27 | 50 | 1.36 | 14.1 | 7.6 |
| 240 | Kevin Slowey | MIN | 13 | 6 | 4.45 | 30 | 28 | 0 | 155.7 | 172 | 21 | 29 | 116 | 1.29 | 17.5 | 4.4 |
| 241 | Homer Bailey | CIN | 4 | 3 | 4.46 | 19 | 19 | 0 | 109.0 | 109 | 11 | 40 | 100 | 1.37 | 21.5 | 8.6 |
| 242 | Joe Saunders | ARI | 9 | 17 | 4.47 | 33 | 33 | 0 | 203.3 | 232 | 25 | 64 | 114 | 1.46 | 13.0 | 7.3 |
| 243 | Edwin Jackson | CWS | 10 | 12 | 4.47 | 32 | 32 | 0 | 209.3 | 214 | 21 | 78 | 181 | 1.39 | 20.1 | 8.6 |
| 244 | Armando Galarraga | DET | 4 | 9 | 4.49 | 25 | 24 | 0 | 144.3 | 143 | 21 | 51 | 74 | 1.34 | 12.0 | 8.3 |
| 245 | Brandon Morrow | TOR | 10 | 7 | 4.49 | 26 | 26 | 0 | 146.3 | 136 | 11 | 66 | 178 | 1.38 | 28.3 | 10.5 |
| 246 | Scott Baker | MIN | 12 | 9 | 4.49 | 29 | 29 | 0 | 170.3 | 186 | 23 | 43 | 148 | 1.34 | 20.4 | 5.9 |
| 247 | Sam LeCure | CIN | 2 | 5 | 4.50 | 15 | 6 | 0 | 48.0 | 50 | 6 | 25 | 37 | 1.56 | 17.1 | 11.5 |
| 248 | Hideki Okajima | BOS | 4 | 4 | 4.50 | 56 | 0 | 0 | 46.0 | 59 | 6 | 20 | 33 | 1.72 | 15.5 | 9.4 |
| 249 | Scott Atchison | BOS | 2 | 3 | 4.50 | 43 | 1 | 0 | 60.0 | 58 | 9 | 19 | 41 | 1.28 | 16.2 | 7.5 |
| 250 | Ivan Nova | NYY | 1 | 2 | 4.50 | 10 | 7 | 0 | 42.0 | 44 | 4 | 17 | 26 | 1.45 | 14.1 | 9.2 |
| 251 | Aaron Heilman | ARI | 5 | 8 | 4.50 | 70 | 0 | 6 | 72.0 | 73 | 9 | 26 | 55 | 1.38 | 17.4 | 8.2 |
| 252 | Ricky Nolasco | FLO | 14 | 9 | 4.51 | 26 | 26 | 0 | 157.7 | 169 | 24 | 33 | 147 | 1.28 | 22.1 | 5.0 |
| 253 | Matt Albers | BAL | 5 | 3 | 4.52 | 62 | 0 | 0 | 75.7 | 78 | 6 | 34 | 49 | 1.48 | 14.9 | 10.3 |
| 254 | Ben Sheets | OAK | 4 | 9 | 4.53 | 20 | 20 | 0 | 119.3 | 123 | 18 | 43 | 84 | 1.39 | 16.4 | 8.4 |
| 255 | Aaron Laffey | CLE | 2 | 3 | 4.53 | 29 | 5 | 0 | 55.7 | 62 | 1 | 28 | 28 | 1.62 | 11.1 | 11.1 |
| 256 | Dave Bush | MIL | 8 | 13 | 4.54 | 32 | 31 | 0 | 174.3 | 198 | 28 | 65 | 107 | 1.51 | 13.7 | 8.3 |
| 257 | Josh Tomlin | CLE | 6 | 4 | 4.56 | 12 | 12 | 0 | 73.0 | 72 | 10 | 19 | 43 | 1.25 | 14.3 | 6.3 |
| 258 | Chris Volstad | FLO | 12 | 9 | 4.58 | 30 | 30 | 0 | 175.0 | 187 | 17 | 60 | 102 | 1.41 | 13.5 | 7.9 |
| 259 | Carlos Villanueva | MIL | 2 | 0 | 4.61 | 50 | 0 | 1 | 52.7 | 48 | 7 | 22 | 67 | 1.33 | 29.0 | 9.5 |
| 260 | Manny Corpas | COL | 3 | 5 | 4.62 | 56 | 0 | 10 | 62.3 | 66 | 7 | 22 | 47 | 1.41 | 17.2 | 8.0 |
| 261 | Jake Peavy | CWS | 7 | 6 | 4.63 | 17 | 17 | 0 | 107.0 | 98 | 13 | 34 | 93 | 1.23 | 20.7 | 7.6 |
| 262 | Eddie Bonine | DET | 4 | 1 | 4.63 | 47 | 1 | 0 | 68.0 | 84 | 7 | 22 | 26 | 1.56 | 8.6 | 7.3 |
| 263 | Jair Jurrjens | ATL | 7 | 6 | 4.64 | 20 | 20 | 0 | 116.3 | 120 | 13 | 42 | 86 | 1.39 | 17.2 | 8.4 |
| 264 | Freddy Garcia | CWS | 12 | 6 | 4.64 | 28 | 28 | 0 | 157.0 | 171 | 23 | 45 | 89 | 1.38 | 13.3 | 6.7 |
| 265 | John Lannan | WSH | 8 | 8 | 4.65 | 25 | 25 | 0 | 143.3 | 175 | 14 | 49 | 71 | 1.56 | 11.0 | 7.6 |
| 266 | Jake Arrieta | BAL | 6 | 6 | 4.66 | 18 | 18 | 0 | 100.3 | 106 | 9 | 48 | 52 | 1.53 | 11.6 | 10.7 |
| 267 | Chan Ho Park | PIT | 4 | 3 | 4.66 | 53 | 0 | 0 | 63.7 | 65 | 9 | 19 | 52 | 1.32 | 18.7 | 6.8 |
| 268 | Jeanmar Gomez | CLE | 4 | 5 | 4.68 | 11 | 11 | 0 | 57.7 | 73 | 7 | 22 | 34 | 1.65 | 12.8 | 8.3 |
| 269 | Daisuke Matsuzaka | BOS | 9 | 6 | 4.69 | 25 | 25 | 0 | 153.7 | 137 | 13 | 74 | 133 | 1.37 | 20.0 | 11.1 |
| 270 | Justin Masterson | CLE | 6 | 13 | 4.70 | 34 | 29 | 0 | 180.0 | 197 | 14 | 73 | 140 | 1.50 | 17.5 | 9.1 |
| 271 | Matt Harrison | TEX | 3 | 2 | 4.71 | 37 | 6 | 2 | 78.3 | 80 | 10 | 39 | 46 | 1.52 | 12.9 | 11.0 |
| 272 | Trevor Bell | LAA | 2 | 5 | 4.72 | 25 | 7 | 0 | 61.0 | 77 | 2 | 21 | 45 | 1.61 | 16.5 | 7.7 |
| 273 | Kyle Kendrick | PHI | 11 | 10 | 4.73 | 33 | 31 | 0 | 180.7 | 199 | 26 | 49 | 84 | 1.37 | 10.9 | 6.4 |
| 274 | Todd Coffey | MIL | 2 | 4 | 4.76 | 69 | 0 | 0 | 62.3 | 65 | 8 | 23 | 56 | 1.41 | 20.4 | 8.4 |
| 275 | Andrew Cashner | CHC | 2 | 6 | 4.80 | 53 | 0 | 0 | 54.3 | 55 | 8 | 30 | 50 | 1.56 | 20.2 | 12.1 |
| 276 | Luke Hochevar | KC | 6 | 6 | 4.81 | 18 | 17 | 0 | 103.0 | 110 | 9 | 37 | 76 | 1.43 | 16.9 | 8.2 |
| 277 | Jason Hammel | COL | 10 | 9 | 4.81 | 30 | 30 | 0 | 177.7 | 201 | 18 | 47 | 141 | 1.40 | 18.3 | 6.1 |
| 278 | Joe Blanton | PHI | 9 | 6 | 4.82 | 29 | 28 | 0 | 175.7 | 206 | 27 | 43 | 134 | 1.42 | 17.5 | 5.6 |
| 279 | Luke French | SEA | 5 | 7 | 4.83 | 16 | 13 | 0 | 87.7 | 88 | 13 | 29 | 37 | 1.33 | 10.0 | 7.8 |
| 280 | Jamie Moyer | PHI | 9 | 9 | 4.84 | 19 | 19 | 0 | 111.7 | 103 | 20 | 20 | 63 | 1.10 | 13.7 | 4.3 |
| 281 | Kanekoa Texeira | KC | 1 | 1 | 4.84 | 43 | 0 | 0 | 61.3 | 73 | 3 | 25 | 33 | 1.60 | 11.9 | 9.0 |
| 282 | Raul Valdes | NYM | 3 | 3 | 4.91 | 38 | 1 | 1 | 58.7 | 59 | 7 | 27 | 56 | 1.47 | 21.4 | 10.3 |
| 283 | Jeff Karstens | PIT | 3 | 10 | 4.92 | 26 | 19 | 0 | 122.7 | 146 | 21 | 27 | 72 | 1.41 | 13.7 | 5.1 |
| 284 | Bud Norris | HOU | 9 | 10 | 4.92 | 27 | 27 | 0 | 153.7 | 151 | 18 | 77 | 158 | 1.48 | 23.1 | 11.3 |
| 285 | Brian Moehler | HOU | 1 | 4 | 4.92 | 20 | 8 | 0 | 56.7 | 66 | 5 | 26 | 28 | 1.62 | 11.2 | 10.4 |
| 286 | Rick Porcello | DET | 10 | 12 | 4.92 | 27 | 27 | 0 | 162.7 | 188 | 18 | 38 | 84 | 1.39 | 12.0 | 5.4 |
| 287 | Alfredo Simon | BAL | 4 | 2 | 4.93 | 49 | 0 | 17 | 49.3 | 54 | 10 | 22 | 37 | 1.54 | 16.7 | 9.9 |
| 288 | Marc Rzepczynski | TOR | 4 | 4 | 4.95 | 14 | 12 | 0 | 63.7 | 72 | 8 | 30 | 57 | 1.60 | 19.9 | 10.5 |
| 289 | James Russell | CHC | 1 | 1 | 4.96 | 57 | 0 | 0 | 49.0 | 55 | 11 | 11 | 42 | 1.35 | 19.2 | 5.0 |
| 290 | Dustin Moseley | NYY | 4 | 4 | 4.96 | 16 | 9 | 0 | 65.3 | 66 | 13 | 27 | 33 | 1.42 | 11.9 | 9.7 |
| 291 | Brad Bergesen | BAL | 8 | 12 | 4.98 | 30 | 28 | 0 | 170.0 | 193 | 26 | 51 | 81 | 1.44 | 10.9 | 6.8 |
| 292 | Blake Hawksworth | STL | 4 | 8 | 4.98 | 45 | 8 | 0 | 90.3 | 113 | 15 | 35 | 61 | 1.64 | 14.9 | 8.6 |
| 293 | Manny Delcarmen | COL | 3 | 4 | 4.99 | 57 | 0 | 0 | 52.3 | 45 | 8 | 32 | 38 | 1.47 | 16.2 | 13.7 |
| 294 | Brian Burres | PIT | 4 | 5 | 4.99 | 20 | 13 | 0 | 79.3 | 87 | 9 | 34 | 45 | 1.53 | 12.4 | 9.4 |
| 295 | Chris Narveson | MIL | 12 | 9 | 4.99 | 37 | 28 | 0 | 167.7 | 172 | 21 | 59 | 137 | 1.38 | 18.9 | 8.1 |
| 296 | Rodrigo Lopez | ARI | 7 | 16 | 5.00 | 33 | 33 | 0 | 200.0 | 227 | 37 | 56 | 116 | 1.42 | 13.3 | 6.4 |
| 297 | Jeff Francis | COL | 4 | 6 | 5.00 | 20 | 19 | 0 | 104.3 | 119 | 11 | 23 | 67 | 1.36 | 15.2 | 5.2 |
| 298 | Manny Parra | MIL | 3 | 10 | 5.02 | 42 | 16 | 0 | 122.0 | 135 | 18 | 63 | 129 | 1.62 | 23.0 | 11.2 |
| 299 | Ronald Belisario | LAD | 3 | 1 | 5.04 | 59 | 0 | 2 | 55.3 | 52 | 6 | 19 | 38 | 1.28 | 16.3 | 8.2 |
| 300 | Jeff Suppan | STL | 3 | 8 | 5.06 | 30 | 15 | 0 | 101.3 | 130 | 13 | 37 | 51 | 1.65 | 11.3 | 8.2 |
| 301 | Blake Wood | KC | 1 | 3 | 5.07 | 51 | 0 | 0 | 49.7 | 54 | 6 | 22 | 31 | 1.53 | 14.1 | 10.0 |
| 302 | Aaron Cook | COL | 6 | 8 | 5.08 | 23 | 23 | 0 | 127.7 | 147 | 11 | 52 | 62 | 1.56 | 10.8 | 9.1 |
| 303 | J. C. Gutierrez | ARI | 0 | 6 | 5.08 | 58 | 0 | 15 | 56.7 | 55 | 13 | 23 | 47 | 1.38 | 19.0 | 9.3 |
| 304 | Tony Peña | CWS | 5 | 3 | 5.10 | 52 | 3 | 0 | 100.7 | 108 | 10 | 45 | 56 | 1.52 | 12.6 | 10.1 |
| 305 | Kevin Millwood | BAL | 4 | 16 | 5.10 | 31 | 31 | 0 | 190.7 | 223 | 30 | 65 | 132 | 1.51 | 15.7 | 7.7 |
| 306 | Paul Maholm | PIT | 9 | 15 | 5.10 | 32 | 32 | 0 | 185.3 | 228 | 15 | 62 | 102 | 1.56 | 12.1 | 7.4 |
| 307 | Felipe Paulino | HOU | 1 | 9 | 5.11 | 19 | 14 | 0 | 91.7 | 95 | 4 | 46 | 83 | 1.54 | 20.2 | 11.2 |
| 308 | Craig Stammen | WSH | 4 | 4 | 5.13 | 35 | 19 | 0 | 128.0 | 151 | 13 | 41 | 85 | 1.50 | 15.1 | 7.3 |
| 309 | Luis Atilano | WSH | 6 | 7 | 5.15 | 16 | 16 | 0 | 85.7 | 96 | 11 | 32 | 40 | 1.49 | 10.4 | 8.3 |
| 310 | Kenshin Kawakami | ATL | 1 | 10 | 5.15 | 18 | 16 | 0 | 87.3 | 98 | 10 | 32 | 59 | 1.49 | 15.1 | 8.2 |
| 311 | Justin Berg | CHC | 0 | 1 | 5.17 | 41 | 0 | 0 | 40.0 | 45 | 3 | 20 | 14 | 1.62 | 7.5 | 10.7 |
| 312 | James Shields | TB | 13 | 15 | 5.18 | 34 | 33 | 0 | 203.3 | 246 | 34 | 51 | 187 | 1.46 | 20.8 | 5.7 |
| 313 | Esmerling Vasquez | ARI | 1 | 6 | 5.20 | 57 | 0 | 0 | 53.7 | 46 | 6 | 38 | 55 | 1.57 | 22.9 | 15.8 |
| 314 | A. J. Burnett | NYY | 10 | 15 | 5.26 | 33 | 33 | 0 | 186.7 | 204 | 25 | 78 | 145 | 1.51 | 17.5 | 9.4 |
| 315 | Mark Hendrickson | BAL | 1 | 6 | 5.26 | 52 | 1 | 0 | 75.3 | 97 | 9 | 20 | 55 | 1.55 | 16.2 | 5.9 |
| 316 | Scot Shields | LAA | 0 | 3 | 5.28 | 43 | 1 | 0 | 46.0 | 45 | 6 | 34 | 39 | 1.72 | 17.9 | 15.6 |
| 317 | Alex Burnett | MIN | 2 | 2 | 5.29 | 41 | 0 | 0 | 47.7 | 52 | 6 | 23 | 37 | 1.57 | 17.5 | 10.9 |
| 318 | Aaron Harang | CIN | 6 | 7 | 5.32 | 22 | 20 | 0 | 111.7 | 139 | 16 | 38 | 82 | 1.59 | 16.3 | 7.5 |
| 319 | Javier Vazquez | NYY | 10 | 10 | 5.32 | 31 | 26 | 0 | 157.3 | 155 | 32 | 65 | 121 | 1.40 | 17.7 | 9.5 |
| 320 | Tim Wakefield | BOS | 4 | 10 | 5.34 | 32 | 19 | 0 | 140.0 | 153 | 19 | 36 | 84 | 1.35 | 13.8 | 5.9 |
| 321 | Kyle Davies | KC | 8 | 12 | 5.34 | 32 | 32 | 0 | 183.7 | 206 | 20 | 80 | 126 | 1.56 | 15.4 | 9.8 |
| 322 | Kevin Correia | SD | 10 | 10 | 5.40 | 28 | 26 | 0 | 145.0 | 152 | 20 | 64 | 115 | 1.49 | 17.9 | 10.0 |
| 323 | Nick Blackburn | MIN | 10 | 12 | 5.42 | 28 | 26 | 0 | 161.0 | 194 | 25 | 40 | 68 | 1.45 | 9.8 | 5.8 |
| 324 | Danys Baez | PHI | 3 | 4 | 5.48 | 51 | 0 | 0 | 47.7 | 55 | 6 | 23 | 28 | 1.64 | 13.0 | 10.6 |
| 325 | Scott Feldman | TEX | 7 | 11 | 5.48 | 29 | 22 | 0 | 141.3 | 181 | 18 | 45 | 75 | 1.60 | 11.7 | 7.0 |
| 326 | Sean O'Sullivan | KC | 4 | 6 | 5.49 | 19 | 14 | 0 | 83.7 | 90 | 15 | 31 | 43 | 1.45 | 11.7 | 8.4 |
| 327 | John Ely | LAD | 4 | 10 | 5.49 | 18 | 18 | 0 | 100.0 | 105 | 12 | 40 | 76 | 1.45 | 17.7 | 9.3 |
| 328 | Jeff Fulchino | HOU | 2 | 1 | 5.51 | 50 | 0 | 0 | 47.3 | 53 | 7 | 22 | 46 | 1.58 | 21.2 | 10.1 |
| 329 | Jeremy Bonderman | DET | 8 | 10 | 5.53 | 30 | 29 | 0 | 171.0 | 187 | 25 | 60 | 112 | 1.44 | 14.9 | 8.0 |
| 330 | Scott Olsen | WSH | 4 | 8 | 5.56 | 17 | 15 | 0 | 81.0 | 93 | 10 | 27 | 53 | 1.48 | 14.8 | 7.6 |
| 331 | Rich Harden | TEX | 5 | 5 | 5.58 | 20 | 18 | 0 | 92.0 | 91 | 18 | 62 | 75 | 1.66 | 17.4 | 14.4 |
| 332 | Hector Ambriz | CLE | 0 | 2 | 5.59 | 34 | 0 | 0 | 48.3 | 68 | 10 | 17 | 37 | 1.76 | 16.5 | 7.6 |
| 333 | Dontrelle Willis | ARI | 2 | 3 | 5.62 | 15 | 13 | 0 | 65.7 | 72 | 6 | 56 | 47 | 1.95 | 14.9 | 17.7 |
| 334 | Chad Gaudin | NYY | 1 | 4 | 5.65 | 42 | 0 | 0 | 65.3 | 73 | 16 | 25 | 53 | 1.50 | 18.0 | 8.5 |
| 335 | Todd Wellemeyer | SF | 3 | 5 | 5.68 | 13 | 11 | 0 | 58.7 | 57 | 12 | 35 | 41 | 1.57 | 15.5 | 13.2 |
| 336 | Gil Meche | KC | 0 | 5 | 5.69 | 20 | 9 | 0 | 61.7 | 65 | 9 | 38 | 41 | 1.67 | 14.6 | 13.5 |
| 337 | Zach Duke | PIT | 8 | 15 | 5.72 | 29 | 29 | 0 | 159.0 | 212 | 25 | 51 | 96 | 1.65 | 13.2 | 7.0 |
| 338 | Sean Gallagher | PIT | 2 | 1 | 5.77 | 46 | 0 | 0 | 57.7 | 62 | 7 | 41 | 43 | 1.79 | 15.8 | 15.0 |
| 339 | Josh Beckett | BOS | 6 | 6 | 5.78 | 21 | 21 | 0 | 127.7 | 151 | 20 | 45 | 116 | 1.54 | 20.1 | 7.8 |
| 340 | Jesse Litsch | TOR | 1 | 5 | 5.79 | 9 | 9 | 0 | 46.7 | 53 | 7 | 15 | 16 | 1.46 | 7.9 | 7.4 |
| 341 | Chris Tillman | BAL | 2 | 5 | 5.87 | 11 | 11 | 0 | 53.7 | 51 | 9 | 31 | 31 | 1.53 | 13.1 | 13.1 |
| 342 | Jesse Chavez | KC | 5 | 5 | 5.89 | 51 | 0 | 0 | 62.7 | 69 | 11 | 23 | 45 | 1.47 | 16.1 | 8.2 |
| 343 | Trevor Hoffman | MIL | 2 | 7 | 5.89 | 50 | 0 | 10 | 47.3 | 49 | 8 | 19 | 30 | 1.44 | 14.6 | 9.3 |
| 344 | Scott Kazmir | LAA | 9 | 15 | 5.94 | 28 | 28 | 0 | 150.0 | 158 | 25 | 79 | 93 | 1.58 | 13.6 | 11.6 |
| 345 | Nate Robertson | PHI | 6 | 8 | 5.95 | 21 | 18 | 0 | 101.3 | 115 | 12 | 42 | 63 | 1.55 | 13.7 | 9.1 |
| 346 | Mike Minor | ATL | 3 | 2 | 5.98 | 9 | 8 | 0 | 40.7 | 53 | 6 | 11 | 43 | 1.57 | 23.2 | 5.9 |
| 347 | Fernando Nieve | NYM | 2 | 4 | 6.00 | 40 | 1 | 0 | 42.0 | 37 | 10 | 22 | 38 | 1.40 | 20.5 | 11.9 |
| 348 | Jeff Weaver | LAD | 5 | 1 | 6.09 | 43 | 0 | 0 | 44.3 | 48 | 5 | 20 | 26 | 1.53 | 13.2 | 10.2 |
| 349 | Bryan Bullington | KC | 1 | 4 | 6.12 | 13 | 5 | 0 | 42.7 | 51 | 6 | 17 | 29 | 1.59 | 14.8 | 8.7 |
| 350 | Daniel McCutchen | PIT | 2 | 5 | 6.12 | 28 | 9 | 0 | 67.7 | 83 | 13 | 28 | 38 | 1.64 | 12.0 | 8.9 |
| 351 | Esmil Rogers | COL | 2 | 3 | 6.12 | 28 | 8 | 0 | 72.0 | 94 | 5 | 26 | 66 | 1.67 | 19.8 | 7.8 |
| 352 | David Huff | CLE | 2 | 11 | 6.21 | 15 | 15 | 0 | 79.7 | 101 | 14 | 34 | 37 | 1.69 | 10.0 | 9.2 |
| 353 | Brian Bannister | KC | 7 | 12 | 6.34 | 24 | 23 | 0 | 127.7 | 158 | 23 | 50 | 77 | 1.63 | 13.3 | 8.6 |
| 354 | Brian Tallet | TOR | 2 | 6 | 6.40 | 34 | 5 | 0 | 77.3 | 84 | 20 | 38 | 53 | 1.58 | 14.9 | 10.7 |
| 355 | Ian Snell | SEA | 0 | 5 | 6.41 | 12 | 8 | 0 | 46.3 | 60 | 10 | 25 | 26 | 1.83 | 11.5 | 11.0 |
| 356 | Kyle Lohse | STL | 4 | 8 | 6.55 | 18 | 18 | 0 | 92.0 | 129 | 9 | 35 | 54 | 1.78 | 12.5 | 8.1 |
| 357 | Jason Marquis | WSH | 2 | 9 | 6.60 | 13 | 13 | 0 | 58.7 | 76 | 9 | 24 | 31 | 1.70 | 11.2 | 8.7 |
| 358 | Brad Lincoln | PIT | 1 | 4 | 6.66 | 11 | 9 | 0 | 52.7 | 66 | 9 | 15 | 25 | 1.54 | 10.4 | 6.2 |
| 359 | Ryan Rowland-Smith | SEA | 1 | 10 | 6.75 | 27 | 20 | 0 | 109.3 | 141 | 25 | 44 | 49 | 1.69 | 9.6 | 8.6 |
| 360 | Dana Eveland | PIT | 3 | 5 | 6.79 | 12 | 10 | 0 | 54.3 | 72 | 4 | 32 | 24 | 1.91 | 9.2 | 12.2 |
| 361 | Oliver Perez | NYM | 0 | 5 | 6.80 | 17 | 7 | 0 | 46.3 | 54 | 9 | 42 | 37 | 2.07 | 15.8 | 17.9 |
| 362 | Chad Qualls | TB | 3 | 4 | 7.32 | 70 | 0 | 12 | 59.0 | 85 | 7 | 21 | 49 | 1.80 | 17.4 | 7.5 |
| 363 | Charlie Morton | PIT | 2 | 12 | 7.57 | 17 | 17 | 0 | 79.7 | 112 | 15 | 26 | 59 | 1.73 | 15.4 | 6.8 |